Mediators of bone resorption and hypercalcemia in cancer - To the editor Journal Article
| Author: | Pugliese. G. |
| Article Title: | Mediators of bone resorption and hypercalcemia in cancer - To the editor |
| Abstract: | To the Editor: Garrett et al. (Aug. 27 issue)1 reported that production of the bone-resorbing cytokine lymphotoxin is related to osteoclastic bone destruction and hypercalcemia in patients with myeloma. Their data indicate that lymphotoxin is the principal mediator of bone resorption, and they state that other mechanisms must also be involved in disturbing calcium homeostasis. The article did not mention the role of prostaglandins, which have been shown to be mediators of the bone resorption and hypercalcemia caused by certain sarcomas and solid tumors.2 Prostaglandin E2 has been shown to be a potent stimulator of bone resorption.3 In rabbits with. © 1988, Massachusetts Medical Society. All rights reserved. |
| Keywords: | osteolysis; letter; neoplasms; hypercalcemia; prostaglandins; bone resorption; cancer; human; priority journal |
| Journal Title: | New England Journal of Medicine |
| Volume: | 318 |
| Issue: | 10 |
| ISSN: | 0028-4793 |
| Publisher: | Massachusetts Medical Society |
| Date Published: | 1988-03-10 |
| Start Page: | 642 |
| End Page: | 643 |
| Language: | English |
| DOI: | 10.1056/nejm198803103181016 |
| PUBMED: | 3344013 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Letter -- Export Date: 6 August 2020 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work