Free fatty acid turnover and lipolysis in septic mechanically ventilated cancer-bearing humans Journal Article


Authors: Levinson, M. R.; Groeger, J. S.; Jeevanandam, M.; Brennan, M. F.
Article Title: Free fatty acid turnover and lipolysis in septic mechanically ventilated cancer-bearing humans
Abstract: Loss of body fat and lean body mass are features of critical illness, and anabolism is difficult to achieve despite parenteral nutrition. Resting energy expenditure (REE), free fatty acid turnover (FFT) and glycerol turnover (glyTO) were measured in septic, mechanically ventilated cancer-bearing patients, both fasting and immediately following or during a glucose infusion providing 87% of REE. No patient was in septic shock nor required pressor support. In the fasting state, REE was greatly elevated compared with basal energy expenditure calculated using the Harris-Benedict equations. Fasting FFT (14.2 ± 0.9 μmol/kg/min) and glyTO (4.7 ± 0.5 μmol/kg/min) were elevated compared with normal humans. Fasting respiratory quotient (RQ) was 0.68 ± 0.02 and did not rise significantly with glucose. Fat appears to be the preferred calorie source in septic, cancer-bearing humans even in the presence of glucose. As similar, but less pronounced, changes have been seen in septic and injured humans without cancer, it is likely that these changes are not cancer-specific. © 1988.
Keywords: adolescent; adult; clinical article; neoplasms; infection; respiration; energy metabolism; critical illness; parenteral nutrition; fatality; middle age; glycerol; fatty acid metabolism; fatty acids, nonesterified; respiration, artificial; cancer; lipolysis; human; male; female; support, non-u.s. gov't
Journal Title: Metabolism
Volume: 37
Issue: 7
ISSN: 0026-0495
Publisher: Elsevier Inc.  
Date Published: 1988-07-01
Start Page: 618
End Page: 625
Language: English
DOI: 10.1016/0026-0495(88)90078-9
PUBMED: 3386532
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 6 August 2020 -- Source: Scopus
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MSK Authors
  1. Murray F Brennan
    992 Brennan
  2. Jeffrey Groeger
    80 Groeger