Neoadjuvant M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) for extravesical urinary tract tumors Journal Article

  

Authors:	Scher, H. I.; Yagoda, A.; Herr, H. W.; Sternberg, C. N.; Morse, M. J.; Sogani, P. C.; Watson, R. C.; Reuter, V.; Whitmore, W. F. Jr; Fair, W. R.
Article Title:	Neoadjuvant M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) for extravesical urinary tract tumors
Abstract:	A total of 11 patients with stage T2-4N0M0 extravesical tumors (prostate, prostatic, urethra, urethra and ureter) received 1 to 4 cycles of neoadjuvant methotrexate, vinblastine, doxorubicin and cisplatin. Of 10 evaluable patients 4 (40 per cent) had downstaging to T0 disease with a clinical complete remission observed in 3 of 5 (60 per cent) with transitional cell tumors of the prostate and prostatic urethra. Four patients with urethral tumors of mixed or nontransitional histology failed to achieve a complete remission. The disease was staged pathologically in 4 patients: 1 had a partial remission and 3 had progression (all 4 had residual disease). Because therapy with methotrexate, vinblastine, doxorubicin and cisplatin induced only significant tumor regression of transitional cell elements of extravesical tumors and because it was ineffective against mixed histological tumors and in preventing new stage Tis lesions, surgical resection of such lesions is required.
Keywords:	clinical article; cisplatin; doxorubicin; methotrexate; staging; histology; vinblastine; remission; transurethral resection; ureter carcinoma; transitional cell carcinoma; normal human; prostate carcinoma; priority journal
Journal Title:	Journal of Urology
Volume:	139
Issue:	3
ISSN:	0022-5347
Publisher:	Elsevier Science, Inc.
Date Published:	1988-03-01
Start Page:	475
End Page:	477
Language:	English
DOI:	10.1016/s0022-5347(17)42496-7
PUBMED:	3343729
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023869635&doi=10.1016%2fS0022-5347%2817%2942496-7&partnerID=40&md5=fb4859b9bb9463d36e64f3d6a6df3227
Notes:	Article -- Export Date: 6 August 2020 -- Source: Scopus

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