Phosphate depletion syndrome: Case report with bone and musle histology findings and review of the literature Journal Article
| Authors: | Levy, Y.; Bansal, M.; Zackson, D. A.; Lane, J.; Shike, M. |
| Article Title: | Phosphate depletion syndrome: Case report with bone and musle histology findings and review of the literature |
| Abstract: | A 44-yr-old woman with a 16-yr history of heavy antacid ingestion was evaluated for severe weight loss, weakness, bone pain, and multiple fractures. Laboratory investigation revealed hypophosphatemia with undetectable phosphate in the urine. Serum parathyroid hormone (PTH), 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D levels were normal. Transiliac bone biopsy revealed evidence of mineralization defect compatible with hypophosphatemic ostoemalacia. Bone densitometry documented decreased bone density with a low mineral content. Management included withdrawal and antacids and provision of phosphate-supplemted enteral nutrition, which resulted in prompt weight gain and resolution of the clincial and biochemical abnormalities. The pathogenesis, diagnosis and histological features of hypophosphatemic oestemalacia are discussed. |
| Keywords: | adult; case report; hypophosphatemia; histology; bone; bone densitometry; muscle; osteomalacia; mineralization; antacid agent; aluminum derivative; human; female; pomacanthus maculosus |
| Journal Title: | Journal of Parenteral and Enteral Nutrition |
| Volume: | 12 |
| Issue: | 3 |
| ISSN: | 0148-6071 |
| Publisher: | Sage Publications |
| Date Published: | 1988-05-01 |
| Start Page: | 313 |
| End Page: | 317 |
| Language: | English |
| DOI: | 10.1177/0148607188012003313 |
| PUBMED: | 3292800 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 6 August 2020 -- Source: Scopus |
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