Distribution of pentamidine in patients with AIDS Journal Article

Authors: Donnelly, H.; Bernard, E. M.; Rothkotter, H.; Gold, J. W. M.; Armstrong, D.
Article Title: Distribution of pentamidine in patients with AIDS
Abstract: We used a bioassay to measure pentamidine concentrations in autopsy specimens from 22 patients with AIDS. Patients received pentamidine isethionate (-4 mg/kg per day) parenterally for Pneumocystis carinii pneumonia; one received monthly prophylaxis. We found that lung levels of 30 ng/g were achieved only after the fifth dose; tissue accumulation was usually greater in the liver, kidney, adrenal, and spleen than in the lung; detectable levels were present in some tissues as late as one year after the last dose; and low but detectable levels were present in the brain of six of 17 patients. Two patients had no detectable lung levels after two days of therapy; one had a level of 17.5 [ig/g after four doses, and two had levels of 30 ng/g after five doses. A more rapid and effective method of delivery, such as aerosol, should achieve higher concentrations earlier. Because pentamidine persists in lung tissue over days to weeks, daily administration may not be necessary. © 1988 by The University of Chicago.
Keywords: clinical article; comparative study; spleen; pneumonia; liver; kidney; drug distribution; tissue distribution; brain; lung; drug tissue level; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; autopsy; pentamidine; protozoon; intravenous drug administration; intramuscular drug administration; adrenal glands; pneumocystis carinii; human; priority journal; pentamidine isethionate; pneumonia, pneumocystis carinii; amidines
Journal Title: Journal of Infectious Diseases
Volume: 157
Issue: 5
ISSN: 0022-1899
Publisher: Oxford University Press  
Date Published: 1988-05-01
Start Page: 985
End Page: 989
Language: English
DOI: 10.1093/infdis/157.5.985
PUBMED: 3258901
PROVIDER: scopus
Notes: Article -- Export Date: 6 August 2020 -- Source: Scopus
Citation Impact
MSK Authors
  1. Donald Armstrong
    222 Armstrong
  2. Edward M Bernard
    48 Bernard
  3. Jonathan W. M. Gold
    59 Gold