Phase II trial of ifosfamide in epidermoid carcinoma of the esophagus: Unexpectant severe toxicity Journal Article
| Authors: | Nanus, D. M.; Kelsen, D. P.; Lipperman, R.; Eisenberger, M. |
| Article Title: | Phase II trial of ifosfamide in epidermoid carcinoma of the esophagus: Unexpectant severe toxicity |
| Abstract: | Thirty-two patients with advanced epidermoid carcinoma of the esophagus were treated with ifosfamide (1.50 gm/m2 daily × 5 days) with uroprotective mesna in a phase II study. Eighteen patients were previously untreated. Of 28 evaluable patients, two (7%) had partial remissions lasting 2+ and 6+ months. Toxicity was predominantly myelosuppression with a median WBC nadir of 1.8 cells/ul. Seven patients required hospitalization for nadir sepsis. Ifosfamide has minimal activity in esophageal cancer and causes severe myelosuppression. © 1988 Kluwer Academic Publishers. |
| Keywords: | adult; clinical article; aged; squamous cell carcinoma; carcinoma, squamous cell; drug efficacy; phase 2 clinical trial; bone marrow suppression; drug screening; ifosfamide; blood; sepsis; mesna; esophagus cancer; phase ii; esophagus tumor; esophageal neoplasms; intravenous drug administration; blood examination; middle age; hematologic tests; drug evaluation; epidermoid carcinoma; epidermoid tumor; human; male; female; priority journal; article; support, u.s. gov't, p.h.s. |
| Journal Title: | Investigational New Drugs |
| Volume: | 6 |
| Issue: | 3 |
| ISSN: | 0167-6997 |
| Publisher: | Springer |
| Date Published: | 1988-09-01 |
| Start Page: | 239 |
| End Page: | 241 |
| Language: | English |
| DOI: | 10.1007/bf00175406 |
| PUBMED: | 3192390 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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