The current state of intraoperative interstitial brachytherapy in lung cancer Journal Article
| Authors: | Hilaris, B. S.; Martini, N. |
| Article Title: | The current state of intraoperative interstitial brachytherapy in lung cancer |
| Abstract: | Low dose-rate intraoperative brachytherapy allows for a more precise tumor localization of the delivered radiation and its easier adaptation to the tumor shape than it is possible with external radiation. As a result a higher dose is usually delivered to the tumor volume and the damage to the normal lung is less. In an attempt to determine the value of lung brachytherapy we provide in this article a complete review of the evolution of brachytherapy in lung cancer at Memorial Sloan-Kettering Cancer Center, an experience which exceeds 1,000 patients. The use of encapsulated sources of I-125, greatly reduced radiation outside the treatment volume and simplified medical and nursing staff radiation protection. Lung brachytherapy in combination with surgery and postoperative external radiation, improved local tumor control in advanced tumors (from 63% to 76%) with no increase in late pulmonary morbidity, but only a modest survival advantage. The results of brachytherapy in patients with early lung cancer who had limited pulmonary reserve, suggest that intraoperative brachytherapy is an effective alternative treatment option. The limited experience with interstitial brachytherapy under fluoroscopic and CT guidance is encouraging, but needs more investigation. © 1988. |
| Keywords: | adult; aged; major clinical study; combined modality therapy; methodology; lung non small cell cancer; carcinoma, non-small-cell lung; lung neoplasms; radiotherapy; lung cancer; iodine 125; intraoperative period; brachytherapy; radioisotope; radioisotope therapy; human; priority journal; lung brachytherapy; lung intraoperative radiation; peroperative radiotherapy |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 15 |
| Issue: | 6 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1988-12-01 |
| Start Page: | 1347 |
| End Page: | 1354 |
| Language: | English |
| DOI: | 10.1016/0360-3016(88)90230-1 |
| PUBMED: | 2848787 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work