Effect of perioperative venous thromboembolism on survival in ovarian, primary peritoneal, and fallopian tube cancer Journal Article


Authors: Black, D.; Iasonos, A.; Ahmed, H.; Chi, D. S.; Barakat, R. R.; Abu-Rustum, N. R.
Article Title: Effect of perioperative venous thromboembolism on survival in ovarian, primary peritoneal, and fallopian tube cancer
Abstract: Objectives: Venous thromboembolism (VTE) affects 15% of cancer patients and is the second leading cause of death in hospitalized cancer patients. The purpose of this study was to describe the overall survival of patients with ovarian, primary peritoneal, and fallopian tube cancers treated for VTE within 30 days of initial surgery. Methods: We reviewed the medical records of all patients who developed VTE within 30 days of primary surgery for stage I-IV epithelial ovarian, tubal, or primary peritoneal cancer at our institution from 1/99 to 4/05. Standard statistical tests were used. Results: Fifty-seven (10%) of 559 patients developed VTE within 30 days of initial surgery. There were no deaths from VTE within 30 days of surgery. With a median follow-up of 2.8 years (range, 0.11-7.3 years), the median overall survival for the entire cohort was 5.9 years (95% CI, 4.6-NR). The proportion of advanced-stage (III-IV) patients within the VTE group compared to the group with no VTE was higher (90% versus 72%; P = 0.0078), as was the proportion of patients with ascites compared to those with none (74% versus 54%; P = 0.0045), and the proportion of patients with residual disease > 1 cm compared to those with ≤ 1 cm (37% versus 19%; P = 0.0021). On multivariate analysis, advanced stage (P < 0.0001), the presence of ascites (P = 0.0210), and residual disease > 1 cm (P < 0.0001) were significant predictors of poorer overall survival. VTE within 30 days of surgery was not found to be independently associated with overall survival (hazard ratio, 1.1; 95% CI, 0.71-1.7); P = 0.65). Conclusions: Previous studies have shown that a significant number of patients undergoing primary surgery for ovarian cancer will develop postoperative VTE, especially those undergoing extensive cytoreductive procedures. In this large cohort of patients with ovarian, tubal, or primary peritoneal cancer, we found no detrimental effects of perioperative VTE on overall survival. © 2007 Elsevier Inc. All rights reserved.
Keywords: survival; adult; controlled study; aged; middle aged; survival rate; retrospective studies; major clinical study; overall survival; disease course; advanced cancer; ascites; cancer staging; follow up; ovarian cancer; ovarian neoplasms; ovary cancer; peritoneum cancer; peritoneal neoplasms; cohort analysis; medical record review; postoperative complications; confidence interval; statistical analysis; minimal residual disease; neoplasm, residual; predictor variable; multivariate analysis; perioperative period; hazard ratio; uterine tube carcinoma; fallopian tube neoplasms; venous thromboembolism; fallopian tube cancer; primary peritoneal cancer; venous thrombosis
Journal Title: Gynecologic Oncology
Volume: 107
Issue: 1
ISSN: 0090-8258
Publisher: Elsevier Inc.  
Date Published: 2007-10-01
Start Page: 66
End Page: 70
Language: English
DOI: 10.1016/j.ygyno.2007.05.040
PUBMED: 17614125
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 7" - "Export Date: 17 November 2011" - "CODEN: GYNOA" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Destin Rene Black
    20 Black
  2. Richard R Barakat
    600 Barakat
  3. Dennis S Chi
    496 Chi
  4. Alexia Elia Iasonos
    182 Iasonos
  5. Hina F Ahmed
    1 Ahmed