Fluorouracil and leucovorin calcium in the treatment of colorectal cancer Journal Article

  


Authors: Melamed, A. J.; Londo, J.; Keaveney, M. E.; Markman, M.
Article Title: Fluorouracil and leucovorin calcium in the treatment of colorectal cancer
Abstract: The overall effectiveness of fluorouracil and leucovorin calcium appears to be at least equivalent to fluorouracil therapy alone. The survival experience of patients treated with fluorouracil and leucovorin calcium is similar to those treated with fluorouracil alone. Data suggest that simultaneous administration of fluorouracil and leucovorin calcium may enhance the antitumor activity of fluorouracil even in tumors previously resistant to fluorouracil alone. In most patients, gastrointestinal toxicity and myelosuppression are dose-limiting effects. The precise relationship between the ratio of reduced folate to fluorouracil will require further definition as will the most efficacious route of administration (e.g., intermittent bolus, continuous infusion, or intraperitoneal regimens).
Keywords: cancer chemotherapy; review; fluorouracil; colorectal cancer; drug cost; folinic acid; folinate calcium; economic aspect; intravenous drug administration; intraperitoneal drug administration; human
Journal Title: Hospital Pharmacy
Volume: 23
Issue: 7
ISSN: 0018-5787
Publisher: Sage Publications  
Date Published: 1988-01-01
Start Page: 669
End Page: 677
Language: English
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023785348&partnerID=40&md5=0f255ee1cf638b078257f448edd77072
Notes: Article -- Source: Scopus