Acute tumor lysis syndrome Journal Article
| Authors: | Keaveney, M. E.; Melamed, A. J. |
| Article Title: | Acute tumor lysis syndrome |
| Abstract: | Acute tumor lysis syndrome can usually be prevented in high risk cancer patients if certain precautions are taken. The syndrome commonly occurs 12 to 48 hours after chemotherapy or radiotherapy and is the result of the rapid and acute lysis of neoplastic cells. Life-threatening metabolic abnormalities may occur due to the rapid release and excretion of large quantities of electrolytes and metabolites into the extracellular fluid. Manifestations of the acute tumor lysis syndrome include hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. Acute tumor lysis may be particularly severe in patients with renal insufficiency, since renal clearance is the primary route of excretion for these metabolites. Further metabolic disturbances may develop including acute renal failure, cardiac arrhythmias, or sudden death. |
| Keywords: | review; cytarabine; methotrexate; cyclophosphamide; furosemide; vincristine; carmustine; hyperuricemia; hyperkalemia; lymphoproliferative disease; amsacrine; burkitt lymphoma; tioguanine; allopurinol; human |
| Journal Title: | Hospital Pharmacy |
| Volume: | 23 |
| Issue: | 5 |
| ISSN: | 0018-5787 |
| Publisher: | Sage Publications |
| Date Published: | 1988-01-01 |
| Start Page: | 473 |
| End Page: | 497 |
| Language: | English |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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