Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary Journal Article
| Authors: | Pippitt, C. H. Jr; Cain, J. M.; Hakes, T. B.; Pierce, V. K.; Lewis, J. L. Jr |
| Article Title: | Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary |
| Abstract: | In view of the rarity of germ cell tumors of the ovary, it is not surprising that little information exists about the indications for and significance of findings at second-look laparotomy in patients with these tumors. For this reason, we have reviewed 16 patients who received primary chemotherapy for malignant germ cell tumors of the ovary at Memorial Sloan-Kettering Cancer Center (MSKCC) between 1976 and 1983. Eleven of them underwent a second-look laparotomy after completion of their therapy. Primary therapy consisted of surgery, usually unilateral oophorectomy, and cis-platinum-based VAB chemotherapy. The histologic diagnoses were six immature teratomas, five endodermal sinus tumors, four mixed germ cell tumors, and one nongestational choriocarcinoma. Stage distribution was as follows: Stage IA, eight patients; Stage IC, one patient; Stage IIA, one patient; Stage III, four patients, and unstaged, two patients. The ages ranged from 15 to 56 years, with the mean of 29 years. All of the 11 patients undergoing second-look laparotomy were found to be free of disease. They are alive and have been continuously free of disease from 9 to 77 months (mean 39 months). This paper discusses primary chemotherapy and the role of the second-look laparotomy and suggests its value in modifying treatment, predicting cure, and safely stopping therapy in patients with germ cell malignancies of the ovary. © 1988 Academic Press, Inc. All rights reserved. |
| Keywords: | adolescent; adult; cancer chemotherapy; clinical article; cisplatin; doxorubicin; combined modality therapy; methotrexate; laparotomy; ovarian neoplasms; dacarbazine; ovary cancer; antineoplastic combined chemotherapy protocols; cyclophosphamide; vinblastine; reoperation; dactinomycin; bleomycin; teratoma; second look surgery; germ cell tumor; choriocarcinoma; chlorambucil; middle age; human; female; priority journal |
| Journal Title: | Gynecologic Oncology |
| Volume: | 31 |
| Issue: | 2 |
| ISSN: | 0090-8258 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1988-10-01 |
| Start Page: | 268 |
| End Page: | 275 |
| Language: | English |
| DOI: | 10.1016/s0090-8258(88)80004-0 |
| PUBMED: | 2458993 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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