Tumor-promoted-enhanced destruction of noninvasive human benign colon tumor cells by cocultivated carcinoma cells Journal Article

  

Authors:	Friedman, E. A.; Buset, M.; Winawer, S. J.
Article Title:	Tumor-promoted-enhanced destruction of noninvasive human benign colon tumor cells by cocultivated carcinoma cells
Abstract:	Colon carcinoma cells are first found as microscopic foci within benign tumors or adenomas. The carcinoma must invade the adenoma which protrudes into the colon lumen before it can infiltrate the bowel wall. A quantitative model for this process has been developed in tissue culture in which human colon carcinoma cells destroy cocultivated adenoma colonies. 43 adenoma colonies were assayed by cocultivation with carcinoma cells. Constitutive secretion of the urokinase form of plasminogen activator by carcinoma cells apparently plays some role in adenoma destruction as inhibition of this protease by the competitive inhibitor benzamidine reversibly inhibited adenoma destruction (p < 0.01). Elevation of plasminogen activator secretion by addition of the tumor promoter 12-tetradecanoylphorbol-13-acetate significantly enhanced the destruction of colonies cultured from tubular adenomas with only mild dysplasia (p < 0.025) and from villous, villotubular and tubular adenomas with moderate to severe dysplasia (p < 0.0005).
Keywords:	human cell; colonic neoplasms; drug effect; pathology; tumor cells, cultured; adenoma; cell culture; colon tumor; tumor cell; carcinoma; colon carcinoma; tissue plasminogen activator; carcinogen; colon adenoma; carcinogens; human; priority journal; article; support, u.s. gov't, p.h.s.
Journal Title:	Digestion
Volume:	40
Issue:	4
ISSN:	0012-2823
Publisher:	S. Karger AG
Date Published:	1988-01-01
Start Page:	197
End Page:	211
Language:	English
DOI:	10.1159/000199656
PUBMED:	3234626
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023823883&doi=10.1159%2f000199656&partnerID=40&md5=8705b7990357bfdb521b1b1486b74500
Notes:	Article -- Export Date: 6 August 2020 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/170673