Anti-fertility and other actions of gossypol analogues Journal Article
| Authors: | Sonenberg, M.; Huang, J. T.; Ren, Y. F.; Su, T. L.; Watanabe, K. A.; Haspel, H. C.; Corin, R. E.; Hoffer, A. P. |
| Article Title: | Anti-fertility and other actions of gossypol analogues |
| Abstract: | From a series of gossypol derivatives studied, we conclude that the carbonyl groups of gossypol are needed for inhibition of erythrocyte anion transport and the hydroxy groups affect but are not essential to that inhibition. In an in vitro mouse erythroleukemia cytocidal assay, the most active compounds were gossypol and apogossypol. The latter was not active in the inhibition of erythrocyte anion transport or in a spermicidal assay. Of the more simple structures related to gossypol, those that were active in the cytocidal and spermicidal assays were bi-aromatic, linked by a 1- and not a 4-carbon chain and had free phenolic hydroxyl groups. These results are included in a discussion of the specificity and mechanism of action of gossypol. © 1988. |
| Keywords: | animal; biological model; biology; physiology; germ cells; clinical research; rats; urogenital system; fertility; testis; spermatozoa; erythrocytes; in vitro; injections; sperm motility; family planning; genitalia; seminiferous tubules; anions; gossypol derivative; gossypol; contraceptive agent; research methodology; contraception; male; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; ion exchange; contraceptive agents, male; contraception research; contraceptive agents--pharmacodynamics; gossypol--pharmacodynamics; male contraception |
| Journal Title: | Contraception |
| Volume: | 37 |
| Issue: | 3 |
| ISSN: | 0010-7824 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1988-03-01 |
| Start Page: | 247 |
| End Page: | 255 |
| Language: | English |
| DOI: | 10.1016/0010-7824(88)90027-3 |
| PUBMED: | 3370997 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 August 2020 -- Source: Scopus |
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