Interactions of antitumor drug ditercalinium with nucleic acids in solutions and in situ Journal Article

  


Authors: Kapuscinski, J.; Traganos, F.; Darzynkiewicz, Z.
Article Title: Interactions of antitumor drug ditercalinium with nucleic acids in solutions and in situ
Abstract: Ditercalinium (7-H-pyridocarbazole dimer), a prospective antitumor drug, is a bis-intercalator characterized by a very high affinity towards nucleic acids. Specificity of binding of this drug has been studied using spectroscopy and flow cytometry. The competition experiments between the drug and 4′,6-diamidino-2-phenylindole · 2HCl (DAPI) or acridine orange indicate that in solution the drug had higher affinity to DNA whereas in situ it binds preferentially to RNA. The results suggest that despite their high affinity towards DNA, the intracellular target of some intercalating drugs may be RNA. © 1988.
Keywords: antineoplastic agents; flow cytometry; cytology; antineoplastic activity; tumor cells, cultured; dna; cell culture; nucleic acids; solutions; nucleic acid conformation; spectroscopy; in vitro; carbazoles; condensation; light scattering; intercalation; intercalating agents; human; priority journal; support, u.s. gov't, p.h.s.; intercalating agent; ditercalinium
Journal Title: Cancer Letters
Volume: 42
Issue: 3
ISSN: 0304-3835
Publisher: Elsevier Ireland Ltd.  
Date Published: 1988-11-01
Start Page: 185
End Page: 191
Language: English
DOI: 10.1016/0304-3835(88)90303-5
PUBMED: 3191470
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023691786&doi=10.1016%2f0304-3835%2888%2990303-5&partnerID=40&md5=5471ebfed7d804c69765f5f120fd0ba4
Notes: Article -- Export Date: 6 August 2020 -- Source: Scopus
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MSK Authors
  1. Zbigniew Darzynkiewicz
    61 Darzynkiewicz
  2. Frank Traganos
    48 Traganos
  3. Jan Kapuscinski
    17 Kapuscinski
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