Hypotension as a manifestation of cardiotoxicity in three patients receiving cisplatin and 5‐fluorouracil Journal Article

  


Authors: Jakubowski, A. A.; Kemeny, N.
Article Title: Hypotension as a manifestation of cardiotoxicity in three patients receiving cisplatin and 5‐fluorouracil
Abstract: Cardiac symptoms, including hypotension, developed in three patients with advanced colorectal carcinoma while being treated with cisplatin (CDDP) and 5‐fluorouracil (5‐FU). In two patients, hypotension was associated with severe left ventricular dysfunction. All three patients required therapy discontinuation. Cardiac enzymes remained normal despite transient electrocardiographic (EKG) changes. The presentation and cardiac evaluation (hemodynamic, echocardiographic, and scintigraphic) of these patients suggest new manifestations of 5‐FU cardiotoxicity that may be influenced by CDDP. The possible pathophysiologic mechanisms are discussed. Copyright © 1988 American Cancer Society
Keywords: adult; case report; cisplatin; fluorouracil; colonic neoplasms; dexamethasone; furosemide; colorectal carcinoma; hypotension; cardiotoxicity; echocardiography; rectal neoplasms; electrocardiography; heart; hemodynamics; intravenous drug administration; diphenhydramine; middle age; human; male; female
Journal Title: Cancer
Volume: 62
Issue: 2
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 1988-07-15
Start Page: 266
End Page: 269
Language: English
DOI: 10.1002/1097-0142(19880715)62:2<266::Aid-cncr2820620207>3.0.Co;2-y
PUBMED: 3383127
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023943631&doi=10.1002%2f1097-0142%2819880715%2962%3a2%3c266%3a%3aAID-CNCR2820620207%3e3.0.CO%3b2-Y&partnerID=40&md5=649c8ea8580995b06414b6a246c32b3c
Notes: Article -- Export Date: 6 August 2020 -- Source: Scopus
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MSK Authors
  1. Ann Jakubowski
    455 Jakubowski
  2. Nancy Kemeny
    543 Kemeny
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