Nonpharmacologic factors in the development of posttreatment nausea with adjuvant chemotherapy for breast cancer Journal Article

  


Authors: Jacobsen, P. B.; Andrykowski, M. A.; Redd, W. H.; Die‐Trill, M.; Hakes, T. B.; Kaufman, R. J.; Currie, V. E.; Holland, J. C.
Article Title: Nonpharmacologic factors in the development of posttreatment nausea with adjuvant chemotherapy for breast cancer
Abstract: A prospective, longitudinal design was used to determine the role of nonpharmacologic factors in the development of posttreatment nausea (PTN). Forty‐five women with no previous chemotherapy experience who were receiving a single regimen of adjuvant chemotherapy for breast cancer were interviewed before and after their first six infusions. Seventy‐one percent of patients developed PTN. The PTN was related to the following: patients' physical status at the onset of treatment; heightened anxiety during infusions; susceptibility to nausea and vomiting after eating certain foods; and expectations of developing chemotherapy‐related nausea. Anxiety during infusions, susceptibility to nausea and vomiting, and expectations of side effects also accounted for differences in the frequency, intensity, and severity of PTN. These findings offer strong support for the view that nonpharmacologic factors contribute to individual differences in gastrointestinal responses to chemotherapy. Copyright © 1988 American Cancer Society
Keywords: adult; clinical article; prednisone; fluorouracil; methotrexate; prospective studies; breast cancer; nausea; antineoplastic combined chemotherapy protocols; cyclophosphamide; vincristine; breast neoplasms; psychological aspect; longitudinal studies; adjuvant chemotherapy; tamoxifen; anxiety; infusions, intravenous; intravenous drug administration; middle age; human; female; priority journal; support, non-u.s. gov't
Journal Title: Cancer
Volume: 61
Issue: 2
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 1988-01-15
Start Page: 379
End Page: 385
Language: English
DOI: 10.1002/1097-0142(19880115)61:2<379::Aid-cncr2820610230>3.0.Co;2-e
PUBMED: 3334973
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023870007&doi=10.1002%2f1097-0142%2819880115%2961%3a2%3c379%3a%3aAID-CNCR2820610230%3e3.0.CO%3b2-E&partnerID=40&md5=a6900840bdf4b540c1eca9b95cee11bd
Notes: Article -- Export Date: 6 August 2020 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Jimmie C B Holland
    379 Holland
  2. Violante Currie
    51 Currie
  3. Thomas B Hakes
    115 Hakes
  4. William H. Redd
    48 Redd
  5. Richard J Kaufman
    13 Kaufman
  6. Paul B. Jacobsen
    42 Jacobsen
Related MSK Work