Pitfalls in the diagnosis of prostatic cancer: Retrospective review of 1791 cases with clinical outcome Journal Article
| Authors: | Berney, D. M.; Fisher, G.; Kattan, M. W.; Oliver, R. T. D.; Møller, H.; Fearn, P.; Eastham, J.; Scardino, P.; Cuzick, J.; Reuter, V. E.; Foster, C. S. |
| Article Title: | Pitfalls in the diagnosis of prostatic cancer: Retrospective review of 1791 cases with clinical outcome |
| Abstract: | Aims: To assess the possible reasons for error in the diagnosis of prostatic cancer with available follow-up data. Method and results: A cohort of 1791 cases of prostatic cancer diagnosed in the UK between 1990 and 1996 was examined. All cases were clinically localized at presentation, treated by non-curative methods and detailed follow-up was available. A panel of genitourinary pathologists reviewed the pathology of all cases. One hundred and thirty-three (7.5%) of cases were reassigned to a non-malignant diagnosis. Where possible, reasons for the initial diagnosis were given. These included severe atrophy, inflammatory induced atypia, sclerosing adenosis, atypical adenomatous hyperplasia and basal cell hyperplasia. Follow-up of these patients showed an extremely low death rate from prostatic cancer: lower than that for the Gleason combined score of five or less tumours diagnosed in this series. Conclusions: Many morphological entities potentially mimic prostatic cancer and may be responsible for misdiagnosis in routine specimens. Continuing education in prostatic morphology and immunohistochemistry may have helped reduce this error rate. © 2007 The Authors. |
| Keywords: | human tissue; retrospective studies; major clinical study; outcome assessment; follow up; follow-up studies; cancer diagnosis; diagnosis, differential; atrophy; cohort analysis; pathology; retrospective study; biopsy; cancer mortality; prostate cancer; gleason score; prostatic neoplasms; prostate; disease severity; diagnostic errors; education, medical, continuing; diagnostic error; prostate hypertrophy; prostatic hyperplasia; united kingdom; pathologist; error; great britain; atypical adenomatous hyperplasia; prostate adenoma |
| Journal Title: | Histopathology |
| Volume: | 51 |
| Issue: | 4 |
| ISSN: | 0309-0167 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2007-10-01 |
| Start Page: | 452 |
| End Page: | 457 |
| Language: | English |
| DOI: | 10.1111/j.1365-2559.2007.02819.x |
| PUBMED: | 17880526 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 12" - "Export Date: 17 November 2011" - "CODEN: HISTD" - "Source: Scopus" |
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