Analogs of tetrahydrofolate directed at folate-dependent purine biosynthetic enzymes. Characteristics of mediated entry and transport-related resistance in L1210 cells for 5,10-dideazatetrahydrofolate and two 10-alkyl derivatives Journal Article

  


Authors: Sirotnak, F. M.; Otter, G. M.; Piper, J. R.; Degraw, J. I.
Article Title: Analogs of tetrahydrofolate directed at folate-dependent purine biosynthetic enzymes. Characteristics of mediated entry and transport-related resistance in L1210 cells for 5,10-dideazatetrahydrofolate and two 10-alkyl derivatives
Keywords: unclassified drug; nonhuman; methotrexate; animal cell; mouse; animal; cell division; drug resistance; tumor cells, cultured; structure-activity relationship; cell culture; folinic acid; cell membrane; folic acid; alkylation; radioisotope; drug transport; biological transport; tetrahydrofolates; leukemia l1210; tetrahydrofolic acid; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; leukemia l 1210; lometrexol; 5,6,7,8 tetrahydro 10 methyl 5,10 dideazafolic acid; 5,6,7,8 tetrahydro 10 ethyl 5,10 dideazafolic acid
Journal Title: Biochemical Pharmacology
Volume: 37
Issue: 24
ISSN: 0006-2952
Publisher: Elsevier Inc.  
Date Published: 1988-12-15
Start Page: 4775
End Page: 4777
Language: English
DOI: 10.1016/0006-2952(88)90351-6
PUBMED: 3202909
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024205346&doi=10.1016%2f0006-2952%2888%2990351-6&partnerID=40&md5=7c6175c52dee67123af2a0d1eab186b7
Notes: Article -- Export Date: 6 August 2020 -- Source: Scopus
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MSK Authors
  1. Francis M Sirotnak
    184 Sirotnak
  2. Glenys M. Otter
    27 Otter
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