The effects of preoperative chemotherapy on the resectability of non-small cell lung carcinoma with mediastinal lymph node metastases (N2 M0) Journal Article
| Authors: | Martini, N.; Kris, M. G.; Gralla, R. J.; Bains, M. S.; McCormack, P. M.; Kaiser, L. R.; Burt, M. E.; Zaman, M. B. |
| Article Title: | The effects of preoperative chemotherapy on the resectability of non-small cell lung carcinoma with mediastinal lymph node metastases (N2 M0) |
| Abstract: | We have defined "clinical N2" disease in non-small cell lung cancer to mean the presence of enlarged metastatic mediastinal nodes evident on plain chest roentgenograms or widening of the carina at bronchoscopy. Forty-one patients with non-small cell carcinoma of the lung and clinical N2 M0 disease presumed operable received 2 to 3 cycles of high-dose cisplatin with vindesine (or vinblastine sulfate) with or without mitomycin-C. Following chemotherapy, 30 patients (73%) had a major radiographic response. Of these patients, 28 had thoracotomy, and 21 (75%) of them had complete resection of the disease, 8 of whom had total sterilization of the tumor proven histologically. An additional 4 patients had limited microscopic foci of residual tumor either in lung or lymph nodes. Survival at 3 years from diagnosis was 34% for all patients, 40% for those who completed the combined treatment (chemotherapy and surgery), and 54% for those who had complete resection with a median follow-up of 44 months and a median survival not yeat attained. © 1988. |
| Keywords: | survival; adult; clinical article; aged; cisplatin; combined modality therapy; chemotherapy; lymph node metastasis; lymphatic metastasis; thoracotomy; antineoplastic combined chemotherapy protocols; carcinoma, non-small-cell lung; lung neoplasms; vinblastine; surgery; mitomycin c; vindesine; lung carcinoma; mitomycin; mediastinum; intravenous drug administration; middle age; mitomycins; human; male; female |
| Journal Title: | Annals of Thoracic Surgery |
| Volume: | 45 |
| Issue: | 4 |
| ISSN: | 0003-4975 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1988-04-01 |
| Start Page: | 370 |
| End Page: | 379 |
| Language: | English |
| DOI: | 10.1016/s0003-4975(98)90007-8 |
| PUBMED: | 2833188 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 August 2020 -- Source: Scopus |
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