Recurrence after negative second-look laparotomy for ovarian cancer: Analysis of risk factors Journal Article
| Authors: | Rubin, S. C.; Hoskins, W. J.; Hakes, T. B.; Markman, M.; Cain, J. M.; Lewis, J. L. Jr |
| Article Title: | Recurrence after negative second-look laparotomy for ovarian cancer: Analysis of risk factors |
| Abstract: | To determine the long-term rate of recurrence and define risk factors for recurrence, we have analyzed clinical information on 83 patients followed up for a minimum of 4 years (median, 69 months) after negative second-look laparotomy. Overall, 21 of 83 patients (25.3%) had a recurrence. Median interval to recurrence was 14 months. Stage, grade, and type of chemotherapy were significantly related to risk of recurrence. In patients with stage I disease only one of 27 (3.7%) had a recurrence. Patients with stage I disease were not included in further analysis of risk factors. In stages II, III, and IV, 20 of 56 patients (35.7%) had a recurrence. Recurrence rates by grade (excluding stage I) are as follows: grade 1, three of 21 (14.3%); grade 2, six of 17 (35.5%), and grade 3, 11 of 17 (64.7%). Platinum-treated patients in stages II, III, and IV had a 50% ( 12 24) recurrence rate compared with 25% in nonplatinum-treated patients ( 8 32) (p = 0.05). Differences in disease-free survival between platinum- and nonplatinum-treated patients were significant at the p = 0.02 level. When treated with platinum-based regimens, more patients will achieve complete clinical remission and subsequently negative second-look laparotomy. However, the recurrence rate in these patients is considerably higher than that in patients treated for longer durations with nonplatinum regimens. © 1988. |
| Keywords: | major clinical study; cancer recurrence; cisplatin; antineoplastic agents; follow-up studies; neoplasm staging; laparotomy; ovarian cancer; ovarian neoplasms; ovary cancer; neoplasm recurrence, local; risk factors; recurrence; risk factor; drug therapy, combination; reoperation; middle age; human; female; priority journal; support, non-u.s. gov't; second-look laparotomy |
| Journal Title: | American Journal of Obstetrics and Gynecology |
| Volume: | 159 |
| Issue: | 5 |
| ISSN: | 0002-9378 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1988-11-01 |
| Start Page: | 1094 |
| End Page: | 1098 |
| Language: | English |
| DOI: | 10.1016/0002-9378(88)90420-6 |
| PUBMED: | 3189442 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 August 2020 -- Source: Scopus |
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