Clinical correlation of endoscopic ultrasonography with pathologic stage and outcome in patients undergoing curative resection for gastric cancer Journal Article
| Authors: | Bentrem, D.; Gerdes, H.; Tang, L.; Brennan, M.; Coit, D. |
| Article Title: | Clinical correlation of endoscopic ultrasonography with pathologic stage and outcome in patients undergoing curative resection for gastric cancer |
| Abstract: | Background: Endoscopic ultrasonography (EUS) is considered valuable for preoperative staging of gastric cancer and defining patient eligibility for enrollment in neoadjuvant protocols. The aim of this study was to correlate EUS staging with pathologic evaluation and outcome in patients undergoing curative R0 resection for gastric cancer. Methods: All patients who underwent preoperative clinical assessment of T/N stage with EUS and subsequent R0 resection for gastric adenocarcinoma between 1993 and 2003 were identified from a prospective database. Patients who received neoadjuvant chemotherapy were excluded. Clinical staging results from preoperative EUS were compared with postoperative pathologic staging results and correlated with clinical outcome. Results: Two hundred twenty-five patients with gastric cancer underwent EUS followed by R0 resection, without preoperative chemotherapy. The accuracy of the individual EUS T stage was 57% (127 of 223) and was 50% for N stage (110 of 218). Although EUS was less able to predict outcome according to individual T stage, patients with lesions ≤T2 on EUS had a significantly better outcome than patients with lesions ≥T3. Preoperative assessment of risk was not predicted by EUS N stage alone. Patients identified as high risk on EUS and those with a combination of serosal invasion and nodal disease had both the highest concordance with pathology and a significantly worse outcome (P = .02). Conclusions: The concordance between EUS and pathologic results was lower than expected for individual T and N stages. Patients with lesions ≤T2 had a significantly better prognosis than patients with more advanced lesions. Individual EUS N stage has limited value in preoperative risk assessment. Combined assessment of serosal invasion and nodal positivity on EUS identifies 77% of patients at risk for death from gastric cancer after curative resection. © 2007 Society of Surgical Oncology. |
| Keywords: | treatment outcome; cancer surgery; retrospective studies; major clinical study; cancer risk; cancer staging; follow-up studies; staging; lymph nodes; lymphatic metastasis; neoplasm staging; diagnostic accuracy; prospective studies; adenocarcinoma; biopsy; risk assessment; correlation analysis; statistical significance; stomach cancer; neoplasm invasiveness; stomach adenocarcinoma; stomach neoplasms; gastroscopy; endoscopic echography; endosonography; preoperative; cancer statistics; esophagoscopy; gastric mucosa; eus; stomach neoplasm; serous membrane |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 14 |
| Issue: | 6 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2007-06-01 |
| Start Page: | 1853 |
| End Page: | 1859 |
| Language: | English |
| DOI: | 10.1245/s10434-006-9037-5 |
| PUBMED: | 17357856 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 36" - "Export Date: 17 November 2011" - "CODEN: ASONF" - "Source: Scopus" |
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