Impact of body size and body composition on bladder cancer outcomes: Risk stratification and opportunity for novel interventions Journal Article
| Authors: | Sanchez, A.; Kissel, S.; Coletta, A.; Scott, J.; Furberg, H. |
| Article Title: | Impact of body size and body composition on bladder cancer outcomes: Risk stratification and opportunity for novel interventions |
| Abstract: | Body size is emerging as a novel and clinically-relevant patient factor in bladder cancer research. Historically, a patient's body mass index (BMI) has been used as a proxy for obesity but it shows inconsistent associations with risk of developing the disease as well as with most clinical outcomes. More specific body composition features can be derived for patients using a variety of methods. To date, skeletal muscle measurements derived from preoperative computed tomography scans have shown the most consistent associations with clinical outcomes. Importantly, skeletal muscle can potentially be modified through resistance training and/or nutritional interventions. Large scale studies that evaluate the prognostic impact of not only body composition features at baseline but also describe changes in body composition post-treatment are needed to move the field forward to ultimately improve clinical outcomes for bladder cancer patients. © 2020 Elsevier Inc. |
| Keywords: | overall survival; review; antineoplastic agent; preoperative evaluation; computer assisted tomography; incidence; exercise; obesity; bladder cancer; diet supplementation; risk assessment; postoperative complication; body mass; body mass index; cancer specific survival; cystectomy; epirubicin; body size; perioperative period; probiotic agent; multivitamin; body composition; neoadjuvant chemotherapy; skeletal muscle; nutrition; clinical outcome; adiposity; muscle mass; human; priority journal; sarcopenia; resistance training; research priority |
| Journal Title: | Urologic Oncology: Seminars and Original Investigations |
| Volume: | 38 |
| Issue: | 9 |
| ISSN: | 1078-1439 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2020-09-01 |
| Start Page: | 713 |
| End Page: | 718 |
| Language: | English |
| DOI: | 10.1016/j.urolonc.2020.03.017 |
| PUBMED: | 32312642 |
| PROVIDER: | scopus |
| PMCID: | PMC8245008 |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
