Head and neck paragangliomas: 30-year experience Journal Article
| Authors: | Valero, C.; Ganly, I.; Shah, J. P. |
| Article Title: | Head and neck paragangliomas: 30-year experience |
| Abstract: | Background: We aimed to review our experience and the changing trends in the management of head and neck paragangliomas (HNPG) over the last three decades. Methods: We retrospectively reviewed 103 patients with HNPG treated at our center (1986-2017). We included patients treated with surgery, radiotherapy, and patients maintained under active surveillance. Results: Of the surgically treated patients (n = 79), 20% (12/59) of the carotid body tumors (CBT) had a cranial nerve deficit as sequela compared to 95% (19/20) of the non-CBT. Radiotherapy controlled growth in all tumors treated with this modality (n = 10). Of the initially observed patients, 70% (14/20) remained stable and did not require additional treatment. Stratifying by decades, there was a progressive increase in patients initially attempted to be observed and a decrease in upfront surgery. No deaths attributable to the HNPG were encountered. Conclusions: Surgery is an effective treatment for CBT. Nonsurgical treatment should be considered for non-CBT. © 2020 Wiley Periodicals, Inc. |
| Keywords: | adult; controlled study; treatment outcome; aged; middle aged; cancer surgery; major clinical study; percutaneous endoscopic gastrostomy; multimodality cancer therapy; cancer patient; follow up; antineoplastic agent; preoperative evaluation; genetic analysis; paraganglioma; computer assisted tomography; mucosa inflammation; cohort analysis; surgical approach; retrospective study; distant metastasis; dysphagia; hospitalization; head and neck neoplasms; conservative treatment; family history; medical record; postoperative hemorrhage; hematoma; adjuvant radiotherapy; vocal cord paralysis; head and neck tumor; radiation dermatitis; chemoradiotherapy; magnetic resonance angiography; noradrenalin; cranial nerve neoplasms; hoarseness; surgical patient; disease surveillance; carotid body tumor; germline mutation; chemodectoma; glomus tumor; human; male; female; priority journal; article; hypoglossal nerve; paragangliomas; artificial embolization; normetadrenalin |
| Journal Title: | Head & Neck |
| Volume: | 42 |
| Issue: | 9 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2020-09-01 |
| Start Page: | 2486 |
| End Page: | 2495 |
| Language: | English |
| DOI: | 10.1002/hed.26277 |
| PUBMED: | 32427418 |
| PROVIDER: | scopus |
| PMCID: | PMC7725473 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 September 2020 -- Source: Scopus |
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