Donor-derived human bone marrow cells contribute to solid organ cancers developing after bone marrow transplantation Journal Article

  

Authors:	Avital, I.; Moreira, A. L.; Klimstra, D. S.; Leversha, M.; Papadopoulos, E. B.; Brennan, M.; Downey, R. J.
Article Title:	Donor-derived human bone marrow cells contribute to solid organ cancers developing after bone marrow transplantation
Abstract:	Bone marrow-derived stem cells have been shown to participate in solid organ repair after tissue injury. Animal models suggest that epithelial malignancies may arise as aberrant stem cell differentiation during tissue repair. We hypothesized that if bone marrow stem cells participate in human neoplasia, then solid organ cancers developing after allogeneic bone marrow transplantation (ABMT) might include malignant cells of donor origin. We identified four male patients who developed solid organ cancers (lung adenocarcinoma, laryngeal squamous cell carcinoma, glioblastoma, and Kaposi sarcoma) after myeloablation, total body irradiation, and ABMT from female donors. Donor-derived malignant cells comprised 2.5%-6% of the tumor cellularity The presence of donor-derived malignant cells in solid organ cancers suggests that human bone marrow-derived stem cells have a role in solid organ cancer's carcinogenesis. However, the nature of this role is yet to be defined. ©AlphaMed Press.
Keywords:	adult; child; controlled study; school child; middle aged; case report; larynx carcinoma; follow-up studies; prospective studies; neoplasms; bone marrow cells; bone marrow; allogenic bone marrow transplantation; carcinogenesis; animalia; whole body radiation; donor; tissue donors; lung adenocarcinoma; glioblastoma; hematopoietic stem cell; kaposi sarcoma; bone marrow transplantation; cancer stem cells; solid organ cancer
Journal Title:	Stem Cells
Volume:	25
Issue:	11
ISSN:	1066-5099
Publisher:	AlphaMed Press
Date Published:	2007-11-01
Start Page:	2903
End Page:	2909
Language:	English
DOI:	10.1634/stemcells.2007-0409
PUBMED:	17690178
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-36249009624&partnerID=40&md5=eaf708e5f3dfdbfb414d781d3505663b
Notes:	--- - "Cited By (since 1996): 26" - "Export Date: 17 November 2011" - "CODEN: STCEE" - "Source: Scopus"

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