Pooled analysis of Day 100 survival for defibrotide-treated patients with hepatic veno-occlusive disease/sinusoidal obstruction syndrome and ventilator or dialysis dependence following haematopoietic cell transplantation Journal Article
| Authors: | Richardson, P. G.; Smith, A. R.; Kernan, N. A.; Lehmann, L.; Soiffer, R. J.; Ryan, R. J.; Tappe, W.; Grupp, S. |
| Article Title: | Pooled analysis of Day 100 survival for defibrotide-treated patients with hepatic veno-occlusive disease/sinusoidal obstruction syndrome and ventilator or dialysis dependence following haematopoietic cell transplantation |
| Abstract: | For patients with untreated hepatic veno-occlusive disease (VOD)/sinusoidal obstruction syndrome (SOS) with multi-organ dysfunction (MOD), mortality is >80%. We conducted a pooled analysis of three studies that assessed Day 100 survival in relationship to MOD severity, with dialysis and/or ventilator dependence representing the most severe organ dysfunction. All patients in the analysis were diagnosed using Baltimore criteria/biopsy. This analysis of patients with VOD/SOS and MOD after haematopoietic cell transplantation (HCT; n = 651) demonstrated higher Day 100 survival rates amongst defibrotide-treated patients with VOD/SOS with less versus more severe forms of MOD. Even patients with severe forms of MOD post-HCT benefitted from defibrotide. © 2020 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd |
| Keywords: | defibrotide; dialysis; ventilator; multi-organ dysfunction; veno-occlusive disease/sinusoidal obstruction syndrome |
| Journal Title: | British Journal of Haematology |
| Volume: | 190 |
| Issue: | 4 |
| ISSN: | 0007-1048 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2020-08-01 |
| Start Page: | 583 |
| End Page: | 587 |
| Language: | English |
| DOI: | 10.1111/bjh.16552 |
| PUBMED: | 32157682 |
| PROVIDER: | scopus |
| PMCID: | PMC7497046 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
