Histological aggressiveness of fluorodeoxyglucose positron-emission tomogram (FDG-PET)-detected incidental thyroid carcinomas Journal Article

  

Authors:	Are, C.; Hsu, J. F.; Ghossein, R. A.; Schoder, H.; Shah, J. P.; Shaha, A. R.
Article Title:	Histological aggressiveness of fluorodeoxyglucose positron-emission tomogram (FDG-PET)-detected incidental thyroid carcinomas
Abstract:	Background: We previously reported a high incidence of primary thyroid cancer in fluorodeoxyglucose positron-emission tomogram (FDG-PET)-detected incidental thyroid abnormalities. The aim of our study was to determine if these FDG-PET-detected thyroid malignancies represent a more-aggressive variant of primary thyroid carcinoma. Materials and methods: All patients that underwent operative intervention for FDG-PET-detected incidental thyroid abnormalities were identified (June 2003 to April 2006). Patients with a diagnosis of primary thyroid carcinoma on final histopathology were included in the study. The patient demographics and histopathological findings were analyzed to identify adverse prognostic features. Results: In 11,500 patients, 17,250 FDG-PET scans were performed; 377 of these patients (3.2% of patients and 2.1% of FDG-PET scans) had findings positive for thyroid abnormality. Of the 32 patients that underwent operative intervention, 22 patients with a final diagnosis of primary thyroid malignancy were included in the study. A greater number of patients [12 patients, (54%)] were noted to harbor poor prognostic variants of primary thyroid carcinoma on final histopathology [tall-cell variant: 11 patients (50%) and poorly differentiated thyroid carcinoma: 1 patient (4%)]. Extra-thyroidal extension (ETE) was noted in the majority of patients [14 patients (63%)]. In patients with tall cell variant on final histopathology, the rate of ETE was even higher [10 patients (90%)]. Conclusion: Thyroid malignancies incidentally detected on FDG-PET scan harbor a high rate of unfavorable prognostic features and may represent a more-aggressive variant of primary thyroid carcinoma. These patients need to be subjected to further investigation with a view to possible operative intervention. © 2007 Society of Surgical Oncology.
Keywords:	adult; clinical article; aged; middle aged; histopathology; positron emission tomography; cancer diagnosis; radiopharmaceuticals; demography; biology; carcinoma, papillary; histology; drug uptake; incidental findings; biopsy, fine-needle; fluorodeoxyglucose f18; positron-emission tomography; thyroid carcinoma; thyroid neoplasms; incidental finding; cancer classification; fluorodeoxyglucose; aggressiveness; fdg-pet scan; incidental thyroid carcinoma
Journal Title:	Annals of Surgical Oncology
Volume:	14
Issue:	11
ISSN:	1068-9265
Publisher:	Springer
Date Published:	2007-11-01
Start Page:	3210
End Page:	3215
Language:	English
DOI:	10.1245/s10434-007-9531-4
PUBMED:	17713821
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-35348887737&partnerID=40&md5=6df8680ee6cf75ad11957d019c04087d
Notes:	--- - "Cited By (since 1996): 22" - "Export Date: 17 November 2011" - "CODEN: ASONF" - "Source: Scopus"

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