Optimizing radiation therapy to boost systemic immune responses in breast cancer: A critical review for breast radiation oncologists Review
| Authors: | Ho, A. Y.; Wright, J. L.; Blitzblau, R. C.; Mutter, R. W.; Duda, D. G.; Norton, L.; Bardia, A.; Spring, L.; Isakoff, S. J.; Chen, J. H.; Grassberger, C.; Bellon, J. R.; Beriwal, S.; Khan, A. J.; Speers, C.; Dunn, S. A.; Thompson, A.; Santa-Maria, C. A.; Krop, I. E.; Mittendorf, E.; King, T. A.; Gupta, G. P. |
| Review Title: | Optimizing radiation therapy to boost systemic immune responses in breast cancer: A critical review for breast radiation oncologists |
| Abstract: | Immunotherapy using immune checkpoint blockade has revolutionized the treatment of many types of cancer. Radiation therapy (RT)—particularly when delivered at high doses using newer techniques—may be capable of generating systemic antitumor effects when combined with immunotherapy in breast cancer. These systemic effects might be due to the local immune-priming effects of RT resulting in the expansion and circulation of effector immune cells to distant sites. Although this concept merits further exploration, several challenges need to be overcome. One is an understanding of how the heterogeneity of breast cancers may relate to tumor immunogenicity. Another concerns the need to develop knowledge and expertise in delivery, sequencing, and timing of RT with immunotherapy. Clinical trials addressing these issues are under way. We here review and discuss the particular opportunities and issues regarding this topic, including the design of informative clinical and translational studies. © 2020 |
| Keywords: | clinical trial; review; cancer radiotherapy; clinical practice; cancer immunotherapy; breast cancer; radiotherapy; tumor antigen; tumor marker; cell heterogeneity; immune response; radiation effects; immunogenicity; clinical research; immunostimulation; metastatic breast cancer; cell expansion; diseases; immunocompetent cell; radiation oncologists; translational research; tumor immunogenicity; human; priority journal; radiation oncologist; antitumor effect; critical review; priming effects |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 108 |
| Issue: | 1 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2020-09-01 |
| Start Page: | 227 |
| End Page: | 241 |
| Language: | English |
| DOI: | 10.1016/j.ijrobp.2020.05.011 |
| PUBMED: | 32417409 |
| PROVIDER: | scopus |
| PMCID: | PMC7646202 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 September 2020 -- Source: Scopus |
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