Preliminary evaluation of in vivo reflectance confocal microscopy features of discoid lupus erythematosus Journal Article

Authors: Ardigo, M.; Maliszewski, I.; Cota, C.; Scope, A.; Sacerdoti, G.; Gonzalez, S.; Berardesca, E.
Article Title: Preliminary evaluation of in vivo reflectance confocal microscopy features of discoid lupus erythematosus
Abstract: Background: Discoid lupus erythematosus (DLE) can simulate other inflammatory diseases both clinically and histologically. In vivo reflectance confocal microscopy (RCM) is a noninvasive, reproducible imaging technique already reported to be useful in the evaluation of several inflammatory skin conditions such as contact dermatitis, psoriasis and Darier disease. Objectives: The aims of our study were to define RCM features of DLE and to evaluate its feasibility in biopsy site selection. Methods: Discoid lesions were selected for RCM evaluation from 10 patients with an established diagnosis of DLE. Subsequently, a 4-mm punch biopsy of the same areas evaluated with RCM was rendered for histopathological examination. Results: A series of RCM features of DLE was identified and shown to correlate well with histopathological evaluation. Interface changes, as well as epidermal, dermal and adnexal inflammatory cell infiltration, were identified with RCM in a high percentage of the lesions. A limitation of RCM examination besides imaging depth was the inability to distinguish lymphocytes from other white blood cells. Conclusions: The utility of RCM as a diagnostic tool for DLE awaits further evaluation, although it appears to be promising for biopsy site selection. © 2007 The Authors.
Keywords: adult; clinical article; human tissue; middle aged; clinical feature; histopathology; reflectance confocal microscopy; confocal microscopy; microscopy, confocal; cell infiltration; patient assessment; in vivo study; biopsy; punch biopsy; feasibility studies; dermatitis; skin cell; epidermis cell; discoid lupus erythematosus; interface dermatitis; leucocyte infiltration; lupus erythematosus, discoid
Journal Title: British Journal of Dermatology
Volume: 156
Issue: 6
ISSN: 0007-0963
Publisher: Blackwell Publishing  
Date Published: 2007-06-01
Start Page: 1196
End Page: 1203
Language: English
DOI: 10.1111/j.1365-2133.2007.07808.x
PUBMED: 17381451
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 18" - "Export Date: 17 November 2011" - "CODEN: BJDEA" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Alon Scope
    123 Scope
  2. Salvador Gonzalez Rodriguez
    203 Rodriguez