Inflammation and outcome after general thoracic surgery Journal Article
| Authors: | Amar, D.; Zhang, H.; Park, B.; Heerdt, P. M.; Fleisher, M.; Thaler, H. T. |
| Article Title: | Inflammation and outcome after general thoracic surgery |
| Abstract: | Objective: To determine whether preoperative inflammation predisposes to major postoperative complications (PC) and poor outcome. Methods: Prospective data collection of 153 consecutive patients aged 73 ± 6 years scheduled for lung resection at a tertiary cancer center. High sensitivity C-reactive protein (CRP) and interleukin (IL)-6 levels were measured before surgery, on arrival to the postanesthesia care unit, and on the first morning after surgery. Results: PC occurred in 9/153 (5.9%) patients. In comparison to patients without PC, those with PC had a greater history of hypertension (P = 0.047), higher frequency of non-steroidal anti-inflammatory drug use (P = 0.007) and had a lower preoperative albumin level, 3.75 ± 0.65 g/dl versus 4.28 ± 0.33 g/dl, P = 0.03. Receiver operating characteristic analysis demonstrated a strong association between PC and preoperative CRP (area under the curve of 0.86), albumin (area under the curve of 0.86) and less so for IL-6 (area under the curve of 0.79). Conclusions: Markers of inflammation, CRP and IL-6, can help distinguish patients who are at high risk for major PC. These preliminary and novel data suggest that in addition to low albumin, a previously described marker of outcome, systemic inflammation is likely to be important in the pathogenesis of important PC. © 2007 European Association for Cardio-Thoracic Surgery. |
| Keywords: | controlled study; aged; major clinical study; anamnesis; hypertension; outcome assessment; preoperative evaluation; c reactive protein; biological markers; lung resection; inflammation; inflammation mediators; c-reactive protein; information processing; postoperative complication; postoperative complications; correlation analysis; albumin; nonsteroid antiinflammatory agent; surgical risk; predictive value of tests; interleukin 6; interleukin-6; tertiary health care; disease predisposition; thorax surgery; hydroxymethylglutaryl coenzyme a reductase inhibitor; receiver operating characteristic; thoracic surgical procedures; recovery room; serum albumin; albumin blood level |
| Journal Title: | European Journal of Cardio-Thoracic Surgery |
| Volume: | 32 |
| Issue: | 3 |
| ISSN: | 1010-7940 |
| Publisher: | Oxford University Press |
| Date Published: | 2007-09-01 |
| Start Page: | 431 |
| End Page: | 434 |
| Language: | English |
| DOI: | 10.1016/j.ejcts.2007.06.017 |
| PUBMED: | 17643996 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 12" - "Export Date: 17 November 2011" - "CODEN: EJCSE" - "Source: Scopus" |
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