A one-pot radiosynthesis of [(18)F]PARPi Journal Article

   


Authors: Wilson, T. C.; Pillarsetty, N.; Reiner, T.
Article Title: A one-pot radiosynthesis of [(18)F]PARPi
Abstract: In this paper, we disclose a new strategy for the radiosynthesis of [18F]PARPi from the corresponding, boc-protected, nitro-precursor. Using a two-step procedure, [18F]PARPi could be isolated in radiochemical yields up to 9.6%. The reaction proceeds via an efficient one-pot, two-step process, allowing for simplification over previous methods that require complex multi-step, multi-pot strategies to be implemented. © 2020 John Wiley & Sons, Ltd.
Keywords: olaparib; radiochemistry; parp inhibitor; fluorine-18; [18f]parpi; pet chemistry
Journal Title: Journal of Labelled Compounds and Radiopharmaceuticals
Volume: 63
Issue: 9
ISSN: 0362-4803
Publisher: Wiley Blackwell  
Date Published: 2020-07-01
Start Page: 419
End Page: 425
Language: English
DOI: 10.1002/jlcr.3847
PUBMED: 32391930
PROVIDER: scopus
PMCID: PMC7551923
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086445491&doi=10.1002%2fjlcr.3847&partnerID=40&md5=3bfb1ffdf6e5ec7ac32917f24f2e469e
Notes: Article -- Export Date: 3 August 2020 -- Source: Scopus
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MSK Authors
  1. Nagavarakishore Pillarsetty
    132 Pillarsetty
  2. Thomas Reiner
    136 Reiner
  3. Thomas Charles Wilson
    6 Wilson
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