Early experience using salvage radiotherapy for relapsed/refractory non-Hodgkin lymphomas after CD19 chimeric antigen receptor (CAR) T cell therapy Journal Article
| Authors: | Imber, B. S.; Sadelain, M.; DeSelm, C.; Batlevi, C.; Brentjens, R. J.; Dahi, P. B.; Giralt, S.; Park, J. H.; Sauter, C.; Scordo, M.; Shah, G.; Perales, M. A.; Palomba, M. L.; Yahalom, J. |
| Article Title: | Early experience using salvage radiotherapy for relapsed/refractory non-Hodgkin lymphomas after CD19 chimeric antigen receptor (CAR) T cell therapy |
| Abstract: | Radiotherapy is potentially an important salvage strategy post-chimeric antigen receptor T cell therapy (CART), but limited data exist. We reviewed 14 patients treated with salvage radiation post-CART progression (SRT). Most received SRT for first post-CART relapse (71%) to sites previously PET-avid pre-CART (79%). Median overall survival (OS) post-SRT was 10 months. Post-SRT, six localized relapses achieved 100% response (3 = complete, 3 = partial), with improved freedom from subsequent relapse (P = 0·001) and OS (P = 0·004) compared to advanced stage relapses. Three were bridged to allogeneic transplantation; at analysis, all were alive/NED. SRT has diverse utility and can integrate with novel agents or transplantation to attempt durable remissions. © 2020 British Society for Haematology and John Wiley & Sons Ltd |
| Keywords: | adult; cancer survival; controlled study; treatment outcome; aged; overall survival; clinical feature; salvage therapy; treatment duration; cancer radiotherapy; radiation dose; cancer staging; recurrence risk; clinical practice; radiotherapy; cohort analysis; retrospective study; nonhodgkin lymphoma; experience; remission; cd19 antigen; cell killing; relapsed/refractory; diffuse large b cell lymphoma; human; male; female; priority journal; article; car t cells; chimeric antigen receptor t cells; chimeric antigen receptor t-cell immunotherapy |
| Journal Title: | British Journal of Haematology |
| Volume: | 190 |
| Issue: | 1 |
| ISSN: | 0007-1048 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2020-07-01 |
| Start Page: | 45 |
| End Page: | 51 |
| Language: | English |
| DOI: | 10.1111/bjh.16541 |
| PUBMED: | 32135029 |
| PROVIDER: | scopus |
| PMCID: | PMC7329607 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 August 2020 -- Source: Scopus |
