Management of mantle cell lymphoma in the era of novel oral agents Review

Authors: Buege, M. J.; Kumar, A.; Dixon, B. N.; Tang, L. A.; Pak, T.; Orozco, J.; Peterson, T. J.; Maples, K. T.
Review Title: Management of mantle cell lymphoma in the era of novel oral agents
Abstract: Objectives: To discuss (1) recent and emerging data for pharmacological management of untreated and relapsed/refractory (R/R) mantle cell lymphoma (MCL) with agents approved in the United States, (2) important considerations for toxicity monitoring and management, and (3) preliminary data and ongoing studies for agents in MCL-specific clinical trials. Data Sources: PubMed/MEDLINE, EMBASE, Google Scholar, product labeling, National Comprehensive Cancer Network, American Cancer Society, and were searched for studies published between January 1, 2017, and January 31, 2020, and key historical trials. Study Selection and Data Extraction: Relevant studies conducted in humans and selected supporting preclinical data were reviewed. Data Synthesis: MCL is a rare but usually aggressive non-Hodgkin lymphoma that most commonly affects the older population. Traditionally, the treatment of MCL has been determined based on transplant eligibility. Newer data suggest that more tolerable frontline therapy may produce outcomes similar to intensive historical induction regimens, possibly precluding fewer patients from autologous stem cell transplant and producing better long-term outcomes in transplant-ineligible patients. In the R/R setting, novel regimens are improving outcomes and changing the landscape of treatment. Relevance to Patient Care and Clinical Practice: This review summarizes and discusses recent and emerging data for management of newly diagnosed and R/R MCL; key supportive care considerations for agents are also discussed. Conclusions: Recent study results are changing management of MCL. Although these data have complicated the picture of regimen selection, increasingly effective and tolerable therapy and additional anticipated data point to a brighter future for patients with MCL. Ā© The Author(s) 2020.
Keywords: oncology; lymphoma; bone marrow transplantation; hematology; clinical pharmacy
Journal Title: Annals of Pharmacotherapy
Volume: 54
Issue: 9
ISSN: 1060-0280
Publisher: Sage Publications  
Date Published: 2020-09-01
Start Page: 879
End Page: 898
Language: English
DOI: 10.1177/1060028020909117
PUBMED: 32079411
PROVIDER: scopus
PMCID: PMC8330616
Notes: Review -- Export Date: 3 August 2020 -- Source: Scopus
Citation Impact
MSK Authors
  1. Anita Kumar
    118 Kumar
  2. Laura Tang
    7 Tang
  3. Brianne N Dixon
    7 Dixon
  4. Kathryn T Maples
    5 Maples
  5. Terry Kheng Pak
    11 Pak
  6. Michael Buege
    11 Buege
  7. Jennifer S Orozco
    8 Orozco