Hybrid PET/MRI enables high-spatial resolution, quantitative imaging of amyloid plaques in an Alzheimer’s disease mouse model Journal Article
| Authors: | Frost, G. R.; Longo, V.; Li, T.; Jonas, L. A.; Judenhofer, M.; Cherry, S.; Koutcher, J.; Lekaye, C.; Zanzonico, P.; Li, Y. M. |
| Article Title: | Hybrid PET/MRI enables high-spatial resolution, quantitative imaging of amyloid plaques in an Alzheimer’s disease mouse model |
| Abstract: | The emergence of PET probes for amyloid plaques and neurofibrillary tangles, hallmarks of Alzheimer disease (AD), enables monitoring of pathology in AD mouse models. However, small-animal PET imaging is limited by coarse spatial resolution. We have installed a custom-fabricated PET insert into our small-animal MRI instrument and used PET/MRI hybrid imaging to define regions of amyloid vulnerability in 5xFAD mice. We compared fluorine-18 [18F]-Florbetapir uptake in the 5xFAD brain by dedicated small-animal PET/MRI and PET/CT to validate the quantitative measurement of PET/MRI. Next, we used PET/MRI to define uptake in six brain regions. As expected, uptake was comparable to wild-type in the cerebellum and elevated in the cortex and hippocampus, regions implicated in AD. Interestingly, uptake was highest in the thalamus, a region often overlooked in AD studies. Development of small-animal PET/MRI enables tracking of brain region-specific pathology in mouse models, which may prove invaluable to understanding AD progression and therapeutic development. © 2020, The Author(s). |
| Journal Title: | Scientific Reports |
| Volume: | 10 |
| ISSN: | 2045-2322 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2020-06-25 |
| Start Page: | 10379 |
| Language: | English |
| DOI: | 10.1038/s41598-020-67284-z |
| PUBMED: | 32587315 |
| PROVIDER: | scopus |
| PMCID: | PMC7316864 |
| DOI/URL: | |
| Notes: | Article -- Erratum issued, see DOI: 10.1038/s41598-020-70134-7 -- Source: Scopus |
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