A systematic literature review of spine neurostimulation therapies for the treatment of pain Review


Authors: Deer, T. R.; Grider, J. S.; Lamer, T. J.; Pope, J. E.; Falowski, S.; Hunter, C. W.; Provenzano, D. A.; Slavin, K. V.; Russo, M.; Carayannopoulos, A.; Shah, J. M.; Harned, M. E.; Hagedorn, J. M.; Bolash, R. B.; Arle, J. E.; Kapural, L.; Amirdelfan, K.; Jain, S.; Liem, L.; Carlson, J. D.; Malinowski, M. N.; Bendel, M.; Yang, A.; Aiyer, R.; Valimahomed, A.; Antony, A.; Craig, J.; Fishman, M. A.; Al-Kaisy, A. A.; Christelis, N.; Rosenquist, R. W.; Levy, R. M.; Mekhail, N.
Review Title: A systematic literature review of spine neurostimulation therapies for the treatment of pain
Abstract: OBJECTIVE: To conduct a systematic literature review of spinal cord stimulation (SCS) for pain. DESIGN: Grade the evidence for SCS. METHODS: An international, interdisciplinary work group conducted literature searches, reviewed abstracts, and selected studies for grading. Inclusion/exclusion criteria included randomized controlled trials (RCTs) of patients with intractable pain of greater than one year's duration. Full studies were graded by two independent reviewers. Excluded studies were retrospective, had small numbers of subjects, or existed only as abstracts. Studies were graded using the modified Interventional Pain Management Techniques-Quality Appraisal of Reliability and Risk of Bias Assessment, the Cochrane Collaborations Risk of Bias assessment, and the US Preventative Services Task Force level-of-evidence criteria. RESULTS: SCS has Level 1 evidence (strong) for axial back/lumbar radiculopathy or neuralgia (five high-quality RCTs) and complex regional pain syndrome (one high-quality RCT). CONCLUSIONS: High-level evidence supports SCS for treating chronic pain and complex regional pain syndrome. For patients with failed back surgery syndrome, SCS was more effective than reoperation or medical management. New stimulation waveforms and frequencies may provide a greater likelihood of pain relief compared with conventional SCS for patients with axial back pain, with or without radicular pain. © 2020 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Keywords: neuromodulation; systematic review; chronic pain; pain management; nerve stimulation; spinal cord stimulation
Journal Title: Pain Medicine
Volume: 21
Issue: 7
ISSN: 1526-2375
Publisher: Oxford University Press  
Date Published: 2020-07-01
Start Page: 1421
End Page: 1432
Language: English
DOI: 10.1093/pm/pnz353
PUBMED: 32034422
PROVIDER: scopus
DOI/URL:
Notes: Article -- Erratum issued, see DOI: 10.1093/pm/pnaa209 -- Export Date: 3 August 2020 -- Source: Scopus
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  1. Jay M Shah
    1 Shah