Maternal programming of social dominance via milk cytokines Journal Article
| Authors: | Taki, F.; Lopez, K.; Zupan, B.; Bergin, P.; Docampo, M. D.; Alves-Bezerra, M.; Toth, J. G.; Chen, Q.; Argyropoulos, K. V.; Barboza, L.; Pickup, E.; Fancher, N.; Hiller, A.; Gross, S.; Cohen, D. E.; van den Brink, M. R. M.; Toth, M. |
| Article Title: | Maternal programming of social dominance via milk cytokines |
| Abstract: | Biological Sciences; Behavioral Neuroscience; Immunology © 2020 The Authors Regular physical activity improves physical and mental health. Here we found that the effect of physical activity extends to the next generation. Voluntary wheel running of dams, from postpartum day 2 to weaning, increased the social dominance and reproductive success, but not the physical/metabolic health, of their otherwise sedentary offspring. The individual's own physical activity did not improve dominance status. Maternal exercise did not disrupt maternal care or the maternal and offspring microbiota. Rather, the development of dominance behavior in the offspring of running mothers could be explained by the reduction of LIF, CXCL1, and CXCL2 cytokines in breast milk. These data reveal a cytokine-mediated lactocrine pathway that responds to the mother's postpartum physical activity and programs offspring social dominance. As dominance behaviors are highly relevant to the individual's survival and reproduction, lactocrine programming could be an evolutionary mechanism by which a mother promotes the social rank of her offspring. © 2020 The Authors |
| Keywords: | immunology; biological sciences; behavioral neuroscience |
| Journal Title: | iScience |
| Volume: | 23 |
| Issue: | 8 |
| ISSN: | 2589-0042 |
| Publisher: | Cell Press |
| Date Published: | 2020-08-21 |
| Start Page: | 101357 |
| Language: | English |
| DOI: | 10.1016/j.isci.2020.101357 |
| PROVIDER: | scopus |
| PMCID: | PMC7390789 |
| PUBMED: | 32712464 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 August 2020 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
616Van Den Brink -
44Argyropoulos -
25Docampo
Related MSK Work