Pharmacotherapy in pediatric hematopoietic cell transplantation Journal Article
| Authors: | Admiraal, R.; Boelens, J. J. |
| Article Title: | Pharmacotherapy in pediatric hematopoietic cell transplantation |
| Abstract: | Hematopoietic cell transplantation (HCT) is a curative treatment option for both malignant and nonmalignant diseases. Success of the procedure mainly depends on disease control and treatment-related complications. Pharmacotherapy plays a major role in HCT and significantly impacts the outcomes. Main drug use within HCT includes conditioning, GvHD prophylaxis, and prevention/treatment of infections.Increasing evidence suggests individualized dosing in (pediatric) HCT may improve outcome. Dose individualization may result in a better predictable drug treatment in terms of safety and efficacy, including timely immune reconstitution after HCT and optimal tumor or disease control, which may result in improved survival chances. |
| Keywords: | relapse; hematopoietic cell transplantation; graft-versus-host disease; conditioning; therapeutic drug monitoring; cellular therapies; individualized dosing |
| Journal Title: | Handbook of Experimental Pharmacology |
| Volume: | 261 |
| ISSN: | 0171-2004 |
| Publisher: | Springer |
| Date Published: | 2020-01-01 |
| Start Page: | 471 |
| End Page: | 489 |
| Language: | English |
| DOI: | 10.1007/164_2019_247 |
| PUBMED: | 31375921 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article; Book Chapter in "Pediatric Pharmacotherapy" Weiss W, Schwab M, van den Anker J, eds. (ISBN: 978-3-030-50493-9)-- Export Date: 3 August 2020 -- Source: Scopus |
