Minority report: The intestinal mycobiota in systemic infections Review
| Authors: | Rolling, T.; Hohl, T. M.; Zhai, B. |
| Review Title: | Minority report: The intestinal mycobiota in systemic infections |
| Abstract: | Compared to bacteria, fungi often exhibit a lower abundance and a higher temporal volatility in the intestinal microbiota. Analysis of fungi in the microbiota (mycobiota) faces technical limitations with tools that were originally developed for analyzing bacteria. Dysbiotic states of the intestinal mycobiota, often associated with disruption of the healthy bacterial microbiota, are characterized by overgrowth (domination) of specific fungal taxa and loss of diversity. Intestinal domination by Candida species has been shown to be a major source of Candida bloodstream infections. Fungal dysbiosis is also linked to the development and treatment response in non-fungal infections, for example Clostridioides difficile colitis and HIV. Further research is needed to define the contribution of intestinal mycobiota to human fungal and non-fungal infections. © 2020 Elsevier Ltd |
| Keywords: | clinical feature; review; nonhuman; demography; infection; human immunodeficiency virus; clostridium difficile infection; bloodstream infection; intestine flora; mycosis; systemic disease; candida; bacterial flora; human; clostridioides difficile; fungal flora; mycobiome |
| Journal Title: | Current Opinion in Microbiology |
| Volume: | 56 |
| ISSN: | 1369-5274 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2020-08-01 |
| Start Page: | 1 |
| End Page: | 6 |
| Language: | English |
| DOI: | 10.1016/j.mib.2020.05.004 |
| PROVIDER: | scopus |
| PUBMED: | 32599521 |
| PMCID: | PMC7744423 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 3 August 2020 -- Source: Scopus |
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