Clinically actionable strategies for studying neural influences in cancer Journal Article
| Authors: | Demir, I. E.; Reyes, C. M.; Alrawashdeh, W.; Ceyhan, G. O.; Deborde, S.; Friess, H.; Görgülü, K.; Istvanffy, R.; Jungwirth, D.; Kuner, R.; Maryanovich, M.; Na'ara, S.; Renders, S.; Saloman, J. L.; Scheff, N. N.; Steenfadt, H.; Stupakov, P.; Thiel, V.; Verma, D.; Yilmaz, B. S.; White, R. A.; Wang, T. C.; Wong, R. J.; Frenette, P. S.; Gil, Z.; Davis, B. M. |
| Article Title: | Clinically actionable strategies for studying neural influences in cancer |
| Abstract: | Neuro-glial activation is a recently identified hallmark of growing cancers. Targeting tumor hyperinnervation in preclinical and small clinical trials has yielded promising antitumor effects, highlighting the need of systematic analysis of neural influences in cancer (NIC). Here, we outline the strategies translating these findings from bench to the clinic. © 2020 Elsevier Inc. Neuro-glial activation is a recently identified hallmark of growing cancers. Targeting tumor hyperinnervation in preclinical and small clinical trials has yielded promising antitumor effects, highlighting the need of systematic analysis of neural influences in cancer (NIC). Here, we outline the strategies translating these findings from bench to the clinic. © 2020 Elsevier Inc. |
| Keywords: | cancer growth; nonhuman; positron emission tomography; cancer pain; angiogenesis; cancer cell; surgeon; glia cell; nerve cell; neuropathic pain; sensory nerve cell; molecularly targeted therapy; breakthrough pain; neurotransmission; autonomic nervous system; oncologist; denervation; human; priority journal; article; malignant neoplasm; solid malignant neoplasm; quantitative sensory testing |
| Journal Title: | Cancer Cell |
| Volume: | 38 |
| Issue: | 1 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2020-07-13 |
| Start Page: | 11 |
| End Page: | 14 |
| Language: | English |
| DOI: | 10.1016/j.ccell.2020.05.023 |
| PUBMED: | 32531270 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 August 2020 -- Source: Scopus |
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