Authors: | Lewis, N. E.; Petrova-Drus, K.; Huet, S.; Epstein-Peterson, Z. D.; Gao, Q.; Sigler, A. E.; Baik, J.; Ozkaya, N.; Moskowitz, A. J.; Kumar, A.; Horwitz, S. M.; Zhang, Y.; Arcila, M. E.; Levine, R. L.; Roshal, M.; Dogan, A.; Xiao, W. |
Article Title: | Clonal hematopoiesis in angioimmunoblastic T-cell lymphoma with divergent evolution to myeloid neoplasms |
Abstract: | TET2 and DNMT3A mutations are frequently identified in T-cell lymphomas of T follicular helper cell origin (TCL-TFH), clonal hematopoiesis (CH), and myeloid neoplasms (MNs). The relationships among these 3 entities, however, are not well understood. We performed comprehensive genomic studies on paired bone marrow and tissue samples as well as on flow cytometry-sorted bone marrow and peripheral blood subpopulations from a cohort of 22 patients with TCL-TFH to identify shared CH-type mutations in various hematopoietic cell compartments. Identical mutations were detected in the neoplastic T-cell and myeloid compartments of 15 out of 22 patients (68%), including TET2 (14/15) and DNMT3A (10/15). Four patients developed MNs, all of which shared CH-type mutations with their TCL-TFH; additional unique genetic alterations were also detected in each patient's TCL-TFH and MN. These data demonstrate that CH is prevalent in patients with TCL-TFH and that divergent evolution of a CH clone may give rise to both TCL-TFH and MNs. © 2020 American Society of Hematology. All rights reserved. |
Keywords: | adult; clinical article; aged; middle aged; gene mutation; human cell; flow cytometry; antineoplastic agent; gene; bone marrow; cohort analysis; molecular cloning; bone marrow biopsy; cell subpopulation; hematopoietic cell; genomics; hematopoiesis; autologous hematopoietic stem cell transplantation; tet2 gene; dna methyltransferase 3a; bone marrow tumor; angioimmunoblastic t cell lymphoma; clonal hematopoiesis; dnmt3a gene; very elderly; human; male; female; priority journal; article; t cell lymphoma of t follicular helper cell origin |
Journal Title: | Blood Advances |
Volume: | 4 |
Issue: | 10 |
ISSN: | 2473-9529 |
Publisher: | American Society of Hematology |
Date Published: | 2020-05-26 |
Start Page: | 2261 |
End Page: | 2271 |
Language: | English |
DOI: | 10.1182/bloodadvances.2020001636 |
PUBMED: | 32442302 |
PROVIDER: | scopus |
PMCID: | PMC7252546 |
DOI/URL: | |
Notes: | Article -- Export Date: 3 August 2020 -- Source: Scopus |