Clonal hematopoiesis in angioimmunoblastic T-cell lymphoma with divergent evolution to myeloid neoplasms Journal Article


Authors: Lewis, N. E.; Petrova-Drus, K.; Huet, S.; Epstein-Peterson, Z. D.; Gao, Q.; Sigler, A. E.; Baik, J.; Ozkaya, N.; Moskowitz, A. J.; Kumar, A.; Horwitz, S. M.; Zhang, Y.; Arcila, M. E.; Levine, R. L.; Roshal, M.; Dogan, A.; Xiao, W.
Article Title: Clonal hematopoiesis in angioimmunoblastic T-cell lymphoma with divergent evolution to myeloid neoplasms
Abstract: TET2 and DNMT3A mutations are frequently identified in T-cell lymphomas of T follicular helper cell origin (TCL-TFH), clonal hematopoiesis (CH), and myeloid neoplasms (MNs). The relationships among these 3 entities, however, are not well understood. We performed comprehensive genomic studies on paired bone marrow and tissue samples as well as on flow cytometry-sorted bone marrow and peripheral blood subpopulations from a cohort of 22 patients with TCL-TFH to identify shared CH-type mutations in various hematopoietic cell compartments. Identical mutations were detected in the neoplastic T-cell and myeloid compartments of 15 out of 22 patients (68%), including TET2 (14/15) and DNMT3A (10/15). Four patients developed MNs, all of which shared CH-type mutations with their TCL-TFH; additional unique genetic alterations were also detected in each patient's TCL-TFH and MN. These data demonstrate that CH is prevalent in patients with TCL-TFH and that divergent evolution of a CH clone may give rise to both TCL-TFH and MNs. © 2020 American Society of Hematology. All rights reserved.
Keywords: adult; clinical article; aged; middle aged; gene mutation; human cell; flow cytometry; antineoplastic agent; gene; bone marrow; cohort analysis; molecular cloning; bone marrow biopsy; cell subpopulation; hematopoietic cell; genomics; hematopoiesis; autologous hematopoietic stem cell transplantation; tet2 gene; dna methyltransferase 3a; bone marrow tumor; angioimmunoblastic t cell lymphoma; clonal hematopoiesis; dnmt3a gene; very elderly; human; male; female; priority journal; article; t cell lymphoma of t follicular helper cell origin
Journal Title: Blood Advances
Volume: 4
Issue: 10
ISSN: 2473-9529
Publisher: American Society of Hematology  
Date Published: 2020-05-26
Start Page: 2261
End Page: 2271
Language: English
DOI: 10.1182/bloodadvances.2020001636
PUBMED: 32442302
PROVIDER: scopus
PMCID: PMC7252546
DOI/URL:
Notes: Article -- Export Date: 3 August 2020 -- Source: Scopus
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MSK Authors
  1. Steven M Horwitz
    430 Horwitz
  2. Ross Levine
    555 Levine
  3. Alison Moskowitz
    189 Moskowitz
  4. Maria Eugenia Arcila
    479 Arcila
  5. Anita Kumar
    73 Kumar
  6. Ahmet Dogan
    243 Dogan
  7. Mikhail Roshal
    103 Roshal
  8. Qi   Gao
    24 Gao
  9. Neval   Ozkaya
    23 Ozkaya
  10. Natasha Elizabeth Lewis
    15 Lewis
  11. Yanming Zhang
    71 Zhang
  12. Wenbin Xiao
    37 Xiao
  13. Sarah Huet
    3 Huet
  14. Jee Yeon Baik
    20 Baik
  15. Allison Marie Sigler
    13 Sigler