Ovarian cancer after prophylactic salpingectomy in a patient with germline BRCA1 mutation Journal Article
| Authors: | Lugo Santiago, N.; Smith, E.; Sarasohn, D.; Cox, M.; Wan, C. S.; Tchabo, N. E.; Awowole, I.; Broach, V.; Chi, D. S. |
| Article Title: | Ovarian cancer after prophylactic salpingectomy in a patient with germline BRCA1 mutation |
| Abstract: | BACKGROUND: Women with germline BRCA1 or BRCA2 mutations have a lifetime risk of ovarian cancer of up to 46%. Opportunistic salpingectomy has been advocated as a risk-reducing strategy owing to increasing recognition of tubal origin, yet evidence of efficacy in this high-risk population is limited. CASE: This is the case of a woman with a BRCA1 mutation who underwent prophylactic mastectomy and bilateral salpingectomy with ovarian retention before the age of 40 years. She did not undergo oophorectomy and subsequently developed stage IV high-grade serous ovarian cancer 4 years after her initial surgery. CONCLUSION: More research is needed to determine the role of prophylactic salpingectomy with delayed oophorectomy, optimal timing of completion oophorectomy, and the risks and benefits compared with up-front risk-reducing salpingo-oophorectomy. |
| Journal Title: | Obstetrics and Gynecology |
| Volume: | 135 |
| Issue: | 6 |
| ISSN: | 0029-7844 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2020-06-01 |
| Start Page: | 1270 |
| End Page: | 1274 |
| Language: | English |
| DOI: | 10.1097/aog.0000000000003864 |
| PUBMED: | 32459417 |
| PROVIDER: | scopus |
| PMCID: | PMC7263355 |
| DOI/URL: | |
| Notes: | Article -- Erratum issued for missing MSK author, see DOI: 10.1097/AOG.0000000000004064 -- Source: Scopus |
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