Response assessment in diffuse intrinsic pontine glioma: Recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group Guidelines
| Authors: | Cooney, T. M.; Cohen, K. J.; Guimaraes, C. V.; Dhall, G.; Leach, J.; Massimino, M.; Erbetta, A.; Chiapparini, L.; Malbari, F.; Kramer, K.; Pollack, I. F.; Baxter, P.; Laughlin, S.; Patay, Z.; Young Poussaint, T.; Warren, K. E. |
| Title: | Response assessment in diffuse intrinsic pontine glioma: Recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group |
| Abstract: | Optimising the conduct of clinical trials for diffuse intrinsic pontine glioma involves use of consistent, objective disease assessments and standardised response criteria. The Response Assessment in Pediatric Neuro-Oncology working group, consisting of an international panel of paediatric and adult neuro-oncologists, clinicians, radiologists, radiation oncologists, and neurosurgeons, was established to address issues and unique challenges in assessing response in children with CNS tumours. A working group was formed specifically to address response assessment in children and young adults with diffuse intrinsic pontine glioma and to develop a consensus on recommendations for response assessment. Response should be assessed using MRI of brain and spine, neurological examination, and anti-inflammatory or antiangiogenic drugs. Clinical imaging standards are defined. As with previous consensus recommendations, these recommendations will need to be validated in prospective clinical trials. © 2020 Elsevier Ltd |
| Keywords: | treatment response; review; bevacizumab; nuclear magnetic resonance imaging; consensus; steroid; childhood cancer; tumor classification; disease exacerbation; drug use; neurology; neurologic examination; pontine glioma; human; priority journal |
| Journal Title: | Lancet Oncology |
| Volume: | 21 |
| Issue: | 6 |
| ISSN: | 1470-2045 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2020-06-01 |
| Start Page: | e330 |
| End Page: | e336 |
| Language: | English |
| DOI: | 10.1016/s1470-2045(20)30166-2 |
| PUBMED: | 32502459 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 July 2020 -- Source: Scopus |
