Complete response and immune-mediated adverse effects with checkpoint blockade: Treatment of mismatch repair-deficient colorectal neuroendocrine carcinoma Journal Article
| Authors: | Whitman, J.; Kardosh, A.; Diaz, L. Jr; Fong, L.; Hope, T.; Onodera, C.; Joseph, N.; Le, D.; Fisher, G.; Bergsland, E. |
| Article Title: | Complete response and immune-mediated adverse effects with checkpoint blockade: Treatment of mismatch repair-deficient colorectal neuroendocrine carcinoma |
| Keywords: | immunohistochemistry; adult; clinical article; human tissue; protein expression; treatment response; middle aged; cancer surgery; single nucleotide polymorphism; somatic mutation; frameshift mutation; prednisone; case report; cancer combination chemotherapy; drug dose reduction; drug withdrawal; methotrexate; cancer staging; drug megadose; nuclear magnetic resonance imaging; follow up; ki 67 antigen; c reactive protein; carboplatin; cancer immunotherapy; multiple cycle treatment; tumor volume; etoposide; gene locus; bradycardia; tumor biopsy; colorectal carcinoma; alanine aminotransferase; aspartate aminotransferase; liver metastasis; colonoscopy; mismatch repair; microsatellite instability; arthritis; fluorodeoxyglucose f 18; hypermetabolism; gene loss; insulin; glucose blood level; glucose; methylprednisolone; proctocolectomy; hypothyroidism; levothyroxine; echocardiography; drug dose increase; insulin dependent diabetes mellitus; chromogranin; coronary artery disease; electrocardiogram; adverse drug reaction; liothyronine; immunopathology; mismatch repair protein pms2; erythrocyte sedimentation rate; thyrotropin; ecg abnormality; hereditary nonpolyposis colorectal cancer; neuroendocrine carcinoma; joint stiffness; synaptophysin; phase 2 clinical trial (topic); thyroxine; autoimmune hepatitis; hypertransaminasemia; heart ejection fraction; diabetic ketoacidosis; heart catheterization; corticosteroid therapy; germline mutation; troponin; indel mutation; myocarditis; multiple drug dose; insulin treatment; ascending colon; human; male; priority journal; article; pembrolizumab; complete heart block; free thyroxine index; 3 hydroxybutyric acid; positron emission tomography-computed tomography; mutl protein homolog 1; heart ventricle wall motion; coronary artery occlusion; free liothyronine index; immune mediated adverse effect; q wave |
| Journal Title: | JCO Precision Oncology |
| Volume: | 3 |
| ISSN: | 2473-4284 |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 2019-11-22 |
| Language: | English |
| DOI: | 10.1200/po.19.00098 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
