A case of high-risk penile epithelioid hemangioendothelioma Journal Article
| Authors: | Wedmid, A.; Masterson, T. A.; Maki, R. G.; Russo, P. |
| Article Title: | A case of high-risk penile epithelioid hemangioendothelioma |
| Abstract: | Background. A 48-year-old, previously healthy man presented to his local urologist with several small, violaceous, indurated lesions along the shaft of his penis and glans, which caused discomfort and penile curvature. Four weeks previously, the lesions were three small painless blemishes. Peyronie disease was initially diagnosed, but the disease progressed despite steroid treatment. Following the results of a biopsy, multifocal angiosarcoma was diagnosed. CT of the chest, abdomen and pelvis was negative for metastatic disease. At this point the patient was referred to a specialist oncology center for further management. Investigations. At the specialty center, the patient underwent physical examination, additional excisional biopsies, and PET-CT. Diagnosis. Penile epithelioid hemangioendothelioma, which is a multifocal, atypical epithelioid vascular tumor. Management. Single-agent chemotherapy using liposomal doxorubicin hydrochloride for eight cycles, followed by 63 Gy of adjuvant external beam radiation therapy to the penis fractionated over 35 treatments. © 2009 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | adult; treatment response; middle aged; case report; doxorubicin; dose response; multimodality cancer therapy; treatment duration; pathophysiology; radiation dose; combined modality therapy; outcome assessment; positron emission tomography; methodology; computer assisted tomography; multiple cycle treatment; risk factors; steroid; angiosarcoma; risk factor; high risk patient; urology; erythema; symptomatology; penis amputation; penile neoplasms; sexual intercourse; penis erection; peyronie disease; desquamation; hemangioendothelioma; penile biopsy; penis disease; penis tumor; hemangioendothelioma, epithelioid |
| Journal Title: | Nature Reviews Urology |
| Volume: | 6 |
| Issue: | 4 |
| ISSN: | 1759-4812 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2009-04-01 |
| Start Page: | 223 |
| End Page: | 227 |
| Language: | English |
| DOI: | 10.1038/nrurol.2009.26 |
| PUBMED: | 19352397 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 30 November 2010" - "Source: Scopus" |
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