Hemodynamic changes associated with mydriatic eye drop administration in anesthetized pediatric patients Journal Article


Authors: Arslan-Carlon, V.; Walline, M. C.; Seier, K.; Tan, K. S.; Abramson, D. H.
Article Title: Hemodynamic changes associated with mydriatic eye drop administration in anesthetized pediatric patients
Abstract: Dilating eye drops are routinely used in pediatric retinoblastoma patients during anesthetized ophthalmologic exams. Information on the systemic effects of ocular mydriatics, especially in anesthetized pediatric patients, is limited. Objective: The primary aim of this study was to analyze hemodynamic changes during mydriatic eye drop administration in anesthetized pediatric patients. Methods: A retrospective chart review was performed for pediatric retinoblastoma patients who underwent MRI with anesthesia. Baseline blood pressure (BP) and heart rate (HR) were charted for each patient at induction. HR and mean arterial pressure (MAP) measurements were recorded at 5, 10, 15, 30, and 45 min after eye drop administration. Secondarily, we included data from 15 patients who received dilating eye drops while under sevoflurane general anesthetic. All patients were dilated with phenylephrine 2.5 or 10% (depending on age) and tropicamide 1%. Results: The final analysis included 176 anesthesia encounters. The results demonstrate no statistically significant deviation of more than 20% from baseline for either HR or MAP. Additionally, we did not detect any difference between patients who were anesthetized with propofol versus sevoflurane. Conclusions: We did not observe significant hemodynamic instability with administration of dilating eye drops during propofol anesthesia. © 2019 S. Karger AG, Basel. Copyright: All rights reserved.
Keywords: child; preschool child; major clinical study; nuclear magnetic resonance imaging; propofol; practice guideline; retinoblastoma; medical record review; retrospective study; general anesthesia; blood pressure; hemodynamics; mean arterial pressure; phenylephrine; heart rate; eye drops; sevoflurane; human; priority journal; article; pediatric anesthesia; pediatric patient; tropicamide
Journal Title: Ocular Oncology and Pathology
Volume: 6
Issue: 3
ISSN: 2296-4681
Publisher: Karger  
Date Published: 2020-05-01
Start Page: 203
End Page: 209
Language: English
DOI: 10.1159/000500593
PROVIDER: scopus
PMCID: PMC7250338
PUBMED: 32509766
DOI/URL:
Notes: Article -- Export Date: 1 June 2020 -- Source: Scopus
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MSK Authors
  1. David H Abramson
    364 Abramson
  2. Kay See   Tan
    210 Tan
  3. Kenneth Seier
    81 Seier