Quality of life concerns in patients with uveal melanoma after initial diagnosis Journal Article

Authors: Barker, C. A.; Kozlova, A.; Shoushtari, A. N.; Hay, J. L.; Francis, J. H.; Abramson, D. H.
Article Title: Quality of life concerns in patients with uveal melanoma after initial diagnosis
Abstract: Patients with uveal melanoma (UM) are known to have quality of life (QOL) issues after treatment, but QOL concerns after initial diagnosis are ill-defined. Objectives: We studied the QOL concerns of patients with UM after initial diagnosis to identify factors associated with QOL. Method: Between September 2011 and May 2016, UM planning to undergo radiotherapy completed the European Organization for Research and Treatment of Cancer (EORTC) core quality of life questionnaire (QLQ)-C30, as well as the Ophthalmic Oncology module, QLQ-OPT30. Demographic, ophthalmic, and tumor related characteristics were recorded. The primary outcome was the QOL score and fraction of patients reporting any or severe symptoms. A multiple stepwise regression model investigated the association of demographic, ophthalmic, and tumor characteristics with QOL. Results: QOL concerns were assessed in 201 subjects. The majority (51/60) of QOL items had a high response rate (≥90%), and internal consistency on scales (median Cronbach α = 0.85) with the most common severe QOL concern being worry about disease recurrence (41%). The most common ophthalmic symptoms reported were vision impairment (81%) and ocular irritation (66%). Multivariable regression modeling demonstrated several significant associations. Conclusions: Severe worry about UM recurrence, ocular irritation, and vision impairment was reported by many patients. Clinicians should be aware of these concerns and implement management strategies. © 2019 S. Karger AG, Basel. Copyright: All rights reserved.
Keywords: adult; controlled study; aged; middle aged; major clinical study; treatment planning; cancer patient; cancer radiotherapy; cancer diagnosis; prospective study; demography; tumor localization; quality of life; tumor volume; cohort analysis; risk factor; disease severity; tumor recurrence; scoring system; brachytherapy; hospital patient; multivariate logistic regression analysis; uvea melanoma; visual impairment; internal consistency; eye irritation; quality of life assessment; very elderly; human; male; female; priority journal; article; patient worry; european organization for research and treatment of cancer quality of life questionnaire core 30; qlq opt30 questionnaire
Journal Title: Ocular Oncology and Pathology
Volume: 6
Issue: 3
ISSN: 2296-4681
Publisher: Karger  
Date Published: 2020-05-01
Start Page: 184
End Page: 195
Language: English
DOI: 10.1159/000502549
PROVIDER: scopus
PMCID: PMC7250345
Notes: Article -- Export Date: 1 June 2020 -- Source: Scopus
Citation Impact
MSK Authors
  1. Jasmine Helen Francis
    123 Francis
  2. David H Abramson
    283 Abramson
  3. Christopher Barker
    140 Barker
  4. Jennifer L Hay
    187 Hay