Cardiovascular mortality among chronic myeloid leukemia patients in the pre-tyrosine kinase inhibitor (TKI) and TKI eras: A surveillance, epidemiology and end results (SEER) analysis Journal Article
| Authors: | Wang, Q.; Jiang, C.; Zhang, Y.; Zhang, Y.; Yue, B.; Zheng-Lin, B.; Zhao, Y.; Mauro, M. J. |
| Article Title: | Cardiovascular mortality among chronic myeloid leukemia patients in the pre-tyrosine kinase inhibitor (TKI) and TKI eras: A surveillance, epidemiology and end results (SEER) analysis |
| Abstract: | Despite remarkable efficacy, there is an emerging concern regarding TKI-associated cardiovascular toxicity in CML. Long term follow-up studies on association between TKI therapy and cardiovascular outcome have been limited. CML patients were accessed from the SEER 18 database from 1992 to 2011. Cardiovascular disease (CVD) specific mortality was calculated comparing the pre-TKI era to the TKI era using the Fine-Gray competing risk model. Overall, the TKI era was associated with a reduced cardiovascular mortality compared with the pre-TKI era (HR = 0.72; 95%CI, 0.59–0.89). Our results argue for continued aggressive screening, identification and management of cardiovascular risk factors among all CML patients, especially the elderly, and further investigation into specific mechanisms, factors and predictors of risks in TKI-treated CML. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group. |
| Keywords: | adult; cancer chemotherapy; aged; middle aged; major clinical study; cancer patient; imatinib; chronic myeloid leukemia; risk assessment; protein tyrosine kinase inhibitor; cardiovascular disease; cardiovascular risk; cancer registry; tyrosine kinase inhibitor; seer; cardiovascular mortality; human; male; female; priority journal; article |
| Journal Title: | Leukemia and Lymphoma |
| Volume: | 61 |
| Issue: | 5 |
| ISSN: | 1042-8194 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2020-05-01 |
| Start Page: | 1147 |
| End Page: | 1157 |
| Language: | English |
| DOI: | 10.1080/10428194.2019.1711074 |
| PUBMED: | 31985308 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 June 2020 -- Source: Scopus |
