Assessing cerebrospinal fluid flow dynamics in pediatric patients with central nervous system tumors treated with intraventricular radioimmunotherapy Journal Article

   

Authors:	Kramer, K.; Donzelli, M.; Nwora, E.; Pandit-Taskar, N.
Article Title:	Assessing cerebrospinal fluid flow dynamics in pediatric patients with central nervous system tumors treated with intraventricular radioimmunotherapy
Abstract:	The incidence of abnormal cerebrospinal fluid (CSF) flow dynamics in children with central nervous system (CNS) tumors before intraventricular therapy has not been described. Methods: We performed a single-institution, retrospective review of patients with primary or metastatic CNS tumors treated between 2003 and 2018 (15 y). Patients underwent 111In-diethylenetriaminepentaacetic acid injection into the CSF intraventricular space followed by nuclear medicine imaging at 90 min, 4 h, 24 h, and 48 h (if required). CSF flow was classified as normal, delayed, asymmetric, or obstructed. Results: In total, 278 CSF flow studies were performed on 224 patients, 202 of whom (90%) were less than 18 y old. Of these, 116 patients (52%) had metastatic CNS neuroblastoma, 57 (25%) had medulloblastoma, and 51 (23%) had other histologic types of CNS tumors. Of the 278 studies, 237 (85%) were normal, 9 (3%) required neurosurgical intervention, 25 (9%) were delayed, and 7 (3%) were asymmetric. Conclusion: Abnormal CSF flow and the necessity for neurosurgical intervention must be considered when attempting to ensure appropriate intraventricular therapy in the pediatric population. © 2020 by the Society of Nuclear Medicine and Molecular Imaging.
Keywords:	radioimmunotherapy; leptomeningeal disease; cerebrospinal flow
Journal Title:	Journal of Nuclear Medicine
Volume:	61
Issue:	5
ISSN:	0161-5505
Publisher:	Society of Nuclear Medicine
Date Published:	2020-05-01
Start Page:	662
End Page:	664
Language:	English
DOI:	10.2967/jnumed.119.232678
PUBMED:	32005772
PROVIDER:	scopus
PMCID:	PMC7198389
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85084960998&doi=10.2967%2fjnumed.119.232678&partnerID=40&md5=14cf0d1424b86d9cd63944c1a2b49079
Notes:	Article -- Export Date: 1 June 2020 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/165971