Developmental mutators and early onset cancer Editorial
| Authors: | Kentsis, A.; Frank, S. A. |
| Title: | Developmental mutators and early onset cancer |
| Abstract: | A new hypothesis suggests that somatic genome remodeling during normal development can cause mutations that explain many early onset cancers in children and adults. © Copyright © 2020 Kentsis and Frank. |
| Keywords: | leukemia; gene mutation; single nucleotide polymorphism; somatic mutation; cancer risk; cancer susceptibility; proto oncogene; childhood cancer; ewing sarcoma; tumor suppressor gene; gene rearrangement; neuroblastoma; early cancer; medulloblastoma; lymphoma; chromosome translocation; rhabdomyosarcoma; genetic predisposition; rhabdoid tumor; prevention; mosaicism; immunoglobulin receptor; developmental gene; pilocytic astrocytoma; human; article; developmental plasticity; solid malignant neoplasm; cancer genetics and genomics; environmental mutagen |
| Journal Title: | Frontiers in Pediatrics |
| Volume: | 8 |
| ISSN: | 2296-2360 |
| Publisher: | Frontiers Media S.A. |
| Date Published: | 2020-04-28 |
| Start Page: | 189 |
| Language: | English |
| DOI: | 10.3389/fped.2020.00189 |
| PROVIDER: | scopus |
| PMCID: | PMC7198762 |
| PUBMED: | 32411637 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 June 2020 -- Source: Scopus |
