Enhancing CAR T cell efficacy: The next step toward a clinical revolution? Journal Article

Authors: Namuduri, M.; Brentjens, R. J.
Article Title: Enhancing CAR T cell efficacy: The next step toward a clinical revolution?
Abstract: Introduction: The field of immunotherapy has witnessed considerable progress over the last two decades. Beginning with the ability to conceptualize CAR T cell therapy as immunotherapeutic approach, to effortlessly genetically modifying T cells, we have now reached the stage of mass production for clinical needs, all within less than quarter of a century. Areas covered: CAR T cell therapy has been tremendously successful in acute leukemia patients, specifically even in relapsed/refractory disease states. However, similar success is yet to be realized in other malignancies. This review article covers the challenges encountered with the current CD19-targeted CARs, as well as specific obstacles faced by adoptive therapy in solid tumors. It also discusses various strategies to counteract these problems. Expert opinion: CD19-directed trials in the past decade have exposed vulnerabilities in the current CAR T cell design, particularly concerning safety aspects, antigen escape, and T cell persistence. Building on these lessons and factoring in the unique challenges associated with immunotherapy in solid tumors will help generate CARs designed for future trials. Also, research related to the production of allogeneic CAR T cell products will boost the patient reach of this unique technology and possibly reduce financial burden. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.
Keywords: review; lymphocyte proliferation; gene targeting; cancer regression; hematologic malignancy; immunotherapy; patient safety; cell migration; adoptive immunotherapy; cd19 antigen; tumor microenvironment; tumor escape; car; human; priority journal; car t cells; solid malignant neoplasm; chimeric antigen receptor t-cell immunotherapy; chimeric antigen therapy; next steps in adoptive immunotherapy
Journal Title: Expert Review of Hematology
Volume: 13
Issue: 5
ISSN: 1747-4086
Publisher: Taylor & Francis Group  
Date Published: 2020-01-01
Start Page: 533
End Page: 543
Language: English
DOI: 10.1080/17474086.2020.1753501
PUBMED: 32267181
PROVIDER: scopus
Notes: Review -- Export Date: 1 June 2020 -- Source: Scopus
Citation Impact
MSK Authors
  1. Renier J Brentjens
    233 Brentjens