Beyond reirradiation: Efficacy and safety of three or more courses of radiation for head and neck malignancies Journal Article
| Authors: | Xu, A. J.; Luo, L.; Leeman, J. E.; Romesser, P. B.; Spielsinger, D.; Sabol, C.; Waldenberg, T.; Brinkman, T.; Riaz, N.; McBride, S.; Kang, J.; Lee, N.; Tsai, C. J. |
| Article Title: | Beyond reirradiation: Efficacy and safety of three or more courses of radiation for head and neck malignancies |
| Abstract: | Purpose: Recurrent head and neck cancers are associated with significant morbidity and mortality. Outcomes of multiple courses of radiation have not yet been described. Methods and Materials: A single institution database was queried to retrospectively review treatment plans and select patients who underwent ≥ 3 courses of radiation to the head and neck region. Results: Thirty-three patients were found to have ≥ 3 courses of radiation with overlapping fields. Median local recurrence free survival after last course of reirradiation was 9.1 months and median overall survival was 10 months. Grade 3 and above toxicities were reported in 15 patients (45%). Grade 4 and above toxicities were reported in seven patients (21%). There was no grade 5 toxicity. 20 patients (61%) underwent subsequent therapies following completion of repeat reirradiation. Conclusions: Repeat reirradiation to the head and neck region is feasible and carries significant risks that are most appropriately managed with a multi-disciplinary team and must be balanced against the potential for local control and opportunities for emerging systemic therapies. © 2020 |
| Keywords: | adult; clinical article; middle aged; overall survival; fatigue; intensity modulated radiation therapy; salvage therapy; skin fistula; radiation dose; follow up; computer assisted tomography; mucosa inflammation; retrospective study; fibrosis; dysphagia; head and neck cancer; recurrent disease; dermatitis; acute toxicity; trismus; bone necrosis; gross tumor volume; radiation toxicity; clinical target volume; head and neck malignancies; osteomyelitis; reirradiation; proton therapy; re-irradiation; local recurrence free survival; planning target volume; human; male; female; priority journal; article |
| Journal Title: | Clinical and Translational Radiation Oncology |
| Volume: | 23 |
| ISSN: | 2405-6308 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2020-07-01 |
| Start Page: | 30 |
| End Page: | 34 |
| Language: | English |
| DOI: | 10.1016/j.ctro.2020.04.009 |
| PROVIDER: | scopus |
| PMCID: | PMC7200775 |
| PUBMED: | 32382663 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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