Beyond reirradiation: Efficacy and safety of three or more courses of radiation for head and neck malignancies Journal Article


Authors: Xu, A. J.; Luo, L.; Leeman, J. E.; Romesser, P. B.; Spielsinger, D.; Sabol, C.; Waldenberg, T.; Brinkman, T.; Riaz, N.; McBride, S.; Kang, J.; Lee, N.; Tsai, C. J.
Article Title: Beyond reirradiation: Efficacy and safety of three or more courses of radiation for head and neck malignancies
Abstract: Purpose: Recurrent head and neck cancers are associated with significant morbidity and mortality. Outcomes of multiple courses of radiation have not yet been described. Methods and Materials: A single institution database was queried to retrospectively review treatment plans and select patients who underwent ≥ 3 courses of radiation to the head and neck region. Results: Thirty-three patients were found to have ≥ 3 courses of radiation with overlapping fields. Median local recurrence free survival after last course of reirradiation was 9.1 months and median overall survival was 10 months. Grade 3 and above toxicities were reported in 15 patients (45%). Grade 4 and above toxicities were reported in seven patients (21%). There was no grade 5 toxicity. 20 patients (61%) underwent subsequent therapies following completion of repeat reirradiation. Conclusions: Repeat reirradiation to the head and neck region is feasible and carries significant risks that are most appropriately managed with a multi-disciplinary team and must be balanced against the potential for local control and opportunities for emerging systemic therapies. © 2020
Keywords: adult; clinical article; middle aged; overall survival; fatigue; intensity modulated radiation therapy; salvage therapy; skin fistula; radiation dose; follow up; computer assisted tomography; mucosa inflammation; retrospective study; fibrosis; dysphagia; head and neck cancer; recurrent disease; dermatitis; acute toxicity; trismus; bone necrosis; gross tumor volume; radiation toxicity; clinical target volume; head and neck malignancies; osteomyelitis; reirradiation; proton therapy; re-irradiation; local recurrence free survival; planning target volume; human; male; female; priority journal; article
Journal Title: Clinical and Translational Radiation Oncology
Volume: 23
ISSN: 2405-6308
Publisher: Elsevier Inc.  
Date Published: 2020-07-01
Start Page: 30
End Page: 34
Language: English
DOI: 10.1016/j.ctro.2020.04.009
PROVIDER: scopus
PMCID: PMC7200775
PUBMED: 32382663
DOI/URL:
Notes: Article -- Source: Scopus
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MSK Authors
  1. Nadeem Riaz
    259 Riaz
  2. Nancy Y. Lee
    620 Lee
  3. Sean Matthew McBride
    158 McBride
  4. Jonathan Eric Leeman
    75 Leeman
  5. Chiaojung Jillian   Tsai
    125 Tsai
  6. Amy Jia Xu
    10 Xu
  7. Leo Yao Luo
    12 Luo
  8. Christopher Sabol
    11 Sabol
  9. Jung Yun Kang
    13 Kang